ReviewMedicines (Basel, Switzerland)2021
Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes.
Review in Medicines (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 62 citations in OpenAlex.
- Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial.Military Medical Research · 2024Trial
- Plasma Proteomic Signatures of Coagulopathy Following Traumatic Injury: Links to Biomechanics and Patient Outcomes.Shock (Augusta, Ga.) · 2026Article
- Estrogen as a therapeutic agent: Targeting endotheliopathy and coagulopathy in trauma.Transfusion · 2026Review
- Phase-dependent efficacy of intravenous amniotic mesenchymal stem cells in a rat spinal cord injury model.Stem cell research & therapy · 2026Article
- Blood product supplementation modulates clotting kinetics, mechanics, and fibrin architecture in an in vitro model of trauma-induced coagulopathy.Thrombosis research · 2026Article
- From molecular networks to precision therapeutics: the evolving landscape of trauma-induced coagulopathy.World journal of emergency surgery : WJES · 2026Review
- Initial TEG 6s parameters for risk stratification of hemorrhage-related outcomes in massively transfused trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Evaluation of Liver Transplantation Outcomes Using Grafts From Brain-Dead Donors With Warfarin-Associated Coagulopathy.Journal of transplantation · 2026Article
- Review
- An analysis of blood transfusion practices in gunshot wound patients at a peripheral trauma-blood centre unit.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Oral anticoagulant reversal and mortality in trauma patients: a multicentre propensity score-matched cohort study.EClinicalMedicine · 2025Article
- Impact of anion gap on in-hospital mortality in trauma-induced coagulopathy patients: a MIMIC-IV study.European journal of medical research · 2025Article
- Cyclone-induced hematological emergencies: preparedness and response from a hematologist's viewpoint.Annals of medicine and surgery (2012) · 2025Review
- Bleeding resuscitation in the ambulance service, an observational study of standard care in Sweden.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Observational
- Comparative Assessment of Thromboelastography and Rotational Thromboelastometry in Trauma-Related Coagulopathy.Cureus · 2025Article
- Traumatic brain injury persistently increases the incidence of both ischemic and hemorrhagic strokes: Potential mechanisms.Progress in neurobiology · 2025Review
- Article
- Clinical Significance of Rotational Thromboelastometry (ROTEM) for Detection of Early Coagulopathy in Trauma Patients: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- DYSREGULATED CLOT MECHANICS AND KINETICS IMPACTED BY INJURY SEVERITY, PREDICT MORTALITY AFTER TRAUMA.Shock (Augusta, Ga.) · 2025Article
- High-dimensional analysis of injured patients reveals distinct circulating proteomic profiles in plasma vs. whole blood resuscitation.Cell reports. Medicine · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coagulopathy induced by major trauma is common, affecting approximately one-third of patients after trauma. It develops independently of iatrogenic, hypothermic, and dilutive causes (such as iatrogenic cause in case of fluid administration), which instead have a pejorative aspect on coagulopathy. Notwithstanding the continuous research conducted over the past decade on Trauma-Induced Coagulopathy (TIC), it remains a life-threatening condition with a significant impact on trauma mortality. We reviewed the current evidence regarding TIC diagnosis and pathophysiological mechanisms and summarized the different iterations of optimal TIC management strategies among which product resuscitation, potential drug administrations, and hemostatis-focused approaches. We have identified areas of ongoing investigation and controversy in TIC management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.