Evidence map›Paper›PMID 33805165›Full record

ArticleGenes2021

A Missense Mutation in the

Fangzheng Xu, Shuwen Shan, Susan Sommerlad, Jennifer M Seddon, Bertram Brenig

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Fangzheng XuInstitute of Veterinary Medicine, University of Goettingen, 37077 Göttingen, Germany.ORCID 0000-0003-3285-832X
Shuwen ShanInstitute of Veterinary Medicine, University of Goettingen, 37077 Göttingen, Germany.
Susan SommerladSchool of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia.
Jennifer M SeddonSchool of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia.ORCID 0000-0003-3789-6878
Bertram BrenigInstitute of Veterinary Medicine, University of Goettingen, 37077 Göttingen, Germany.ORCID 0000-0002-7635-9656
University of Göttingen · DEThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital deafness is prevalent among modern dog breeds, including Australian Stumpy Tail Cattle Dogs (ASCD). However, in ASCD, no causative gene has been identified so far. Therefore, we performed a genome-wide association study (GWAS) and whole genome sequencing (WGS) of affected and normal individuals. For GWAS, 3 bilateral deaf ASCDs, 43 herding dogs, and one unaffected ASCD were used, resulting in 13 significantly associated loci on 6 chromosomes, i.e., CFA3, 8, 17, 23, 28, and 37. CFA37 harbored a region with the most significant association (-log

Indexed as

Mutation, MissenseAnimalsAustraliaDog DiseasesDogsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHearing Loss, SensorineuralHigh-Throughput Nucleotide SequencingKruppel-Like Transcription FactorsMalePenetranceWhole Genome SequencingKruppel-Like Transcription FactorsAustralian stumpy tail cattle dogbrainstem auditory evoked responsedeafnessgenome wide association studykruppel-like factor 7

Identifiers

PMID33805165
PMCPMC8064056
OpenAlexW3150459974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.