ReviewMaterials (Basel, Switzerland)2021
Titanium and Protein Adsorption: An Overview of Mechanisms and Effects of Surface Features.
Review in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed.
- Beyond Bactericidal: Plasma Surface Engineering to Defeat Food Matrix-Conditioning Layers.Comprehensive reviews in food science and food safety · 2026Review
- Toward Dynamic Biomimetic Biomaterials: Temporal Coupling of Flavonoid-Induced Cellular Responses and 3D-Printed PLA Scaffold Evolution.Biomimetics (Basel, Switzerland) · 2026Article
- Nanotube Size Alters Corrosion Behavior, Mechanical Properties, and Biological Interactions of Anodized Ti6Al7Nb.ACS omega · 2026Article
- Biomedical titanium-tantalum alloys for orthopedic implant applications: From manufacturing to biological performance.Bioactive materials · 2026Review
- Proteomic signature of the acquired salivary pellicle on zirconia and its role in modulating oral biofilms formation.Odontology · 2026Article
- Protein adsorption at material interface: mechanistic design framework for engineering ceramic scaffolds for bone repair applications.Biomedical engineering online · 2026Review
- Integrating Structures and Biology: Cellular and Molecular Interactions with Functionally Graded Spinal Cage Designs.International journal of molecular sciences · 2026Review
- Time-Dependent Electrochemical Behaviour and Surface Response of Ti6Al7Nb and Ti6Al4V Alloys in Albumin-Containing PBS.Materials (Basel, Switzerland) · 2026Article
- Radical-Mediated, Substrate-Independent Fabrication of Hybrid Solid-Hydrogel Materials With Tunable Crosslinking: An Initiator- and Crosslinker-Free Approach.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Influence of the Topography of Zirconium Treated with Laser Micropatterning on Periodontal Ligament Stem Cells: An In Vitro Study.Journal of functional biomaterials · 2026Article
- Single step nanosecond laser structuring for cost effective functional titanium surfaces with topography driven preosteoblast adhesion.Scientific reports · 2026Article
- Differential Neutrophil Responses to Smooth Titanium: A Double-Edged Sword for the Abutment-Gingival Interface (An In Vitro Study).International journal of dentistry · 2026Article
- Salivary protein adsorption on titanium abutments: a comparative study of edentulous and partially edentulous patients.Frontiers in oral health · 2026Article
- Laminin functionalization of zirconia abutments modulates early oral biofilm formation in vitro.Journal of oral microbiology · 2026Article
- Simplified chemical deposition of CuJournal of materials science. Materials in medicine · 2025Article
- Toward Rational Design of Ion-Exchange Nanofiber Membranes: Meso-Scale Computational Approaches.Membranes · 2025Review
- Augmenting Bone Formation by Implanting Dedifferentiated Fat Cell-Loaded Cotton-like Graft Materials in a Rat Bone Defect Model.Bioengineering (Basel, Switzerland) · 2025Article
- Multiscale interface engineering in biohybrid composites for biomedical applications.Materials today. Bio · 2025Review
- In Vitro Assessment of a Novel Piranha-Passivated Dental Implant Surface Against Oral Biofilm Formation.Clinical oral implants research · 2025Article
- Micro-Arc Oxidation of Ti-45Nb Alloy: Surface Characteristics and Corrosion Behavior for Potential Biomedical Application.ACS omega · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium and its alloys, specially Ti6Al4V, are among the most employed materials in orthopedic and dental implants. Cells response and osseointegration of implant devices are strongly dependent on the body-biomaterial interface zone. This interface is mainly defined by proteins: They adsorb immediately after implantation from blood and biological fluids, forming a layer on implant surfaces. Therefore, it is of utmost importance to understand which features of biomaterials surfaces influence formation of the protein layer and how to guide it. In this paper, relevant literature of the last 15 years about protein adsorption on titanium-based materials is reviewed. How the surface characteristics affect protein adsorption is investigated, aiming to provide an as comprehensive a picture as possible of adsorption mechanisms and type of chemical bonding with the surface, as well as of the characterization techniques effectively applied to model and real implant surfaces. Surface free energy, charge, microroughness, and hydroxylation degree have been found to be the main surface parameters to affect the amount of adsorbed proteins. On the other hand, the conformation of adsorbed proteins is mainly dictated by the protein structure, surface topography at the nano-scale, and exposed functional groups. Protein adsorption on titanium surfaces still needs further clarification, in particular concerning adsorption from complex protein solutions. In addition, characterization techniques to investigate and compare the different aspects of protein adsorption on different surfaces (in terms of roughness and chemistry) shall be developed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.