ReviewInternational journal of molecular sciences2021
How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Red blood cell distribution width-albumin ratio as predictor of mortality in patients with cardiac disease: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Prognostic value of prognostic nutritional index in patients with heart failure: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Malnutrition Severity Drives Mortality in Geriatric Heart Failure: A Multicenter Extreme Gradient Boosting Analysis.Reviews in cardiovascular medicine · 2026Article
- Establishment and validation of a machine learning-based predictive model for in-hospital mortality risk in acute myocardial infarction patients complicated with diabetes mellitus.Frontiers in cardiovascular medicine · 2026Article
- Malnutrition risk factors and a pre-post evaluation of a multicomponent management program in older inpatients with chronic heart failure: a single-centre retrospective study.Frontiers in nutrition · 2026Article
- Correlation of Controlling Nutritional Status Score and Systemic Immune-Inflammation Index With Frailty and Prognosis in Chronic Heart Failure Patients With Atrial Fibrillation.Cardiology research and practice · 2026Article
- A study on dietary diversification intervention for elderly patients with chronic heart failure who can eat by mouth.Frontiers in nutrition · 2026Article
- Association between geriatric nutritional risk index and risk of heart failure: a cross-sectional study.BMC cardiovascular disorders · 2025Article
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- Impact of advanced lung cancer inflammation index on all-cause mortality among patients with heart failure: a systematic review and meta-analysis with reconstructed time-to-event data.Cardio-oncology (London, England) · 2025Review
- Geriatric nutritional risk index as a predictor of 30-day and 365-day mortality in patients with acute myocardial infarction: a retrospective cohort study using the MIMIC-IV database.Frontiers in nutrition · 2025Article
- Heart failure: mechanistic insights and precision therapeutic strategies.Frontiers in cardiovascular medicine · 2025Review
- Obesity paradox in patients with reduced ejection fraction eligible for device implantation - an observational study.ESC heart failure · 2024Observational
- Tyrosine to threonine ratio was related to heart failure with reduced or mildly reduced ejection fraction.ESC heart failure · 2024Article
- Total Glucosides of Paeony Ameliorate Myocardial Injury in Chronic Heart Failure Rats by Suppressing PARP-1.Journal of cardiovascular translational research · 2024Article
- Advanced lung cancer inflammation index combined with geriatric nutritional risk index predict all-cause mortality in heart failure patients.BMC cardiovascular disorders · 2023Article
- Essential Amino Acids-Rich Diet Increases Cardiomyocytes Protection in Doxorubicin-Treated Mice.Nutrients · 2023Article
- miR-182-5p combined with brain-derived neurotrophic factor assists the diagnosis of chronic heart failure and predicts a poor prognosis.Journal of cardiothoracic surgery · 2022Article
- Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic heart failure (CHF) is a disease with important clinical and socio-economic ramifications. Malnutrition and severe alteration of the protein components of the body (protein disarrangements), common conditions in CHF patients, are independent correlates of heart dysfunction, disease progression, and mortality. Autophagy, a prominent occurrence in the heart of patients with advanced CHF, is a self-digestive process that prolongs myocardial cell lifespan by the removal of cytosolic components, such as aging organelles and proteins, and recycles the constituent elements for new protein synthesis. However, in specific conditions, excessive activation of autophagy can lead to the destruction of molecules and organelles essential to cell survival, ultimately leading to organ failure and patient death. In this review, we aim to describe the experimental and clinical evidence supporting a pathophysiological role of nutrition and autophagy in the progression of CHF. The understanding of the mechanisms underlying the interplay between nutrition and autophagy may have important clinical implications by providing molecular targets for innovative therapeutic strategies in CHF patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.