ArticleJournal of clinical medicine2021
Prognostic Value of Reduced Heart Rate Reserve during Exercise in Hypertrophic Cardiomyopathy.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise Training in Hypertrophic Cardiomyopathy: A Systematic Review, Meta-analysis, and Meta-regression.Sports medicine - open · 2026Pooled it
- Hypertrophic Cardiomyopathy: Current Perspectives.Reviews in cardiovascular medicine · 2025Review
- Physical cardiac rehabilitation effects on cardio-metabolic outcomes in the patients with hypertrophic cardiomyopathy: a systematic review.American journal of cardiovascular disease · 2024Review
- Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy.Medicina (Kaunas, Lithuania) · 2023Article
- ABCDEG Stress Echocardiography in Aortic Stenosis.Diagnostics (Basel, Switzerland) · 2023Review
- Prognostic Value of Transthoracic Doppler Echocardiography Coronary Flow Velocity Reserve in Patients With Asymmetric Hypertrophic Cardiomyopathy.Journal of the American Heart Association · 2021Article
- Stress Echo 2030: The Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging.Journal of clinical medicine · 2021Article
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Authors and funding
33 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSympathetic dysfunction can be evaluated by heart rate reserve (HRR) with exercise test.
objectivesTo determine the value of HRR in predicting outcome of patients with hypertrophic cardiomyopathy (HCM).
methodsWe enrolled 917 HCM patients (age = 49 ± 15 years, 516 men) assessed with exercise stress echocardiography (ESE) in 11 centres. ESE modality was semi-supine bicycle in 51 patients (6%), upright bicycle in 476 (52%), and treadmill in 390 (42%). During ESE, we assessed left ventricular outflow tract obstruction (LVOTO), stress-induced new regional wall motion abnormalities (RWMA), and HRR (peak/rest heart rate, HR). By selection, all patients completed the follow-up. Mortality was the predetermined outcome measure Results: During ESE, RWMA occurred in 22 patients (2.4%) and LVOTO (≥50 mmHg) in 281 (30.4%). HRR was 1.90 ± 0.40 (lowest quartile ≤ 1.61, highest quartile > 2.13). Higher resting heart rate (odds ratio 1.027, 95% CI: 1.018-1.036,
conclusionsA blunted HRR during ESE predicts survival independently of RWMA in HCM patients.
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