ArticleInternational journal of molecular sciences2021
Examining the Impact of Squaric Acid as a Crosslinking Agent on the Properties of Chitosan-Based Films.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Cross-Linkable Protein Nanofiber Aerogels for the Removal of Cationic and Anionic Dyes.ACS materials Au · 2026Article
- Green Deep Eutectic Solvents for Functionalizing Chitosan-Dialdehyde Materials with Varied Crosslinker Content.Materials (Basel, Switzerland) · 2026Article
- Box-Behnken Design Assisted Optimization and Characterization of Chitosan Film for Simultaneous Topical Delivery of Ascorbic Acid and Metronidazole.Pharmaceutics · 2025Article
- Gelatin-Sodium Alginate Hydrogels Cross-Linked by Squaric Acid and Dialdehyde Starch as a Potential Bio-Ink.Polymers · 2024Article
- Article
- The adenine-modified edible chitosan films containing choline chloride and citric acid mixture.Scientific reports · 2023Article
- Functionalised Hybrid Collagen-Elastin for Acellular Cutaneous Substitute Applications.Polymers · 2023Article
- Synthesis and Comparative Studies of Glucose Oxidase Immobilized on FeNanomaterials (Basel, Switzerland) · 2022Article
- Dialdehyde Starch Nanocrystals as a Novel Cross-Linker for Biomaterials Able to Interact with Human Serum Proteins.International journal of molecular sciences · 2022Article
- Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization.Polymers · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hydrogels based on chitosan are very versatile materials which can be used for tissue engineering as well as in controlled drug delivery systems. One of the methods for obtaining a chitosan-based hydrogel is crosslinking by applying different components. The objective of the present study was to obtain a series of new crosslinked chitosan-based films by means of solvent casting method. Squaric acid-3,4-dihydroxy-3-cyclobutene-1,2-dione-was used as a safe crosslinking agent. The effect of the squaric acid on the structural, mechanical, thermal, and swelling properties of the formed films was determined. It was established that the addition of the squaric acid significantly improved Young's modulus, tensile strength, and thermal stability of the obtained materials. Moreover, it should be stressed that the samples consisting of chitosan and squaric acid were characterized by a higher swelling than pure chitosan. The detailed characterization proved that squaric acid could be used as a new effective crosslinking agent.
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Registered trials
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