ArticleBrain sciences2021
Aerobic Exercise and Stretching as Add-On to Inpatient Treatment for Depression Have No Differential Effects on Stress-Axis Activity, Serum-BDNF, TNF-Alpha and Objective Sleep Measures.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06775548 (Effects of Exercises and Vitamins on Oxidative Stress & Inflammatory Markers Among Patients with Depression), which is not on this map. Cited by 13 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Exercises and Vitamins on Oxidative Stress & Inflammatory Markers Among Patients with Depression
Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Dose-response relationship of exercise interventions on sleep quality in patients with depression: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Disentangling the biological mechanisms underlying the effects of physical exercise in major depressive disorder: a comprehensive systematic review of randomized controlled trials.Psychological medicine · 2025Pooled it
- Effectiveness of exercise intervention on children and adolescents with depression: a systematic review and meta-analysis of randomized controlled trial.Frontiers in psychiatry · 2025Pooled it
- Comparative Effectiveness of Multiple Exercise Interventions in the Treatment of Mental Health Disorders: A Systematic Review and Network Meta-Analysis.Sports medicine - open · 2022Pooled it
- Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Adolescents With a High Burden of New-Onset Mood Symptoms After Sport-Related Concussion Benefit From Prescribed Aerobic Exercise, a Secondary Analysis of 2 Randomized Controlled Trials.Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2025Trial
- Effects of Regular Exercise on Peripheral Brain-Derived Neurotrophic Factor in Neurological and Non-Neurological Populations: A Meta-Analysis with Meta-Regression.Brain sciences · 2025Review
- Effect of Different Exercise Modalities on Inflammatory Markers in Individuals with Depressive Disorder: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Effects of Aerobic Exercises at Different Intensities on Sleep Quality in Individuals with Depression: A Systematic Review and Meta-Analysis.Nature and science of sleep · 2025Review
- A scoping review of the effect of chronic stretch training on sleep quality in people with sleep disorders.European journal of applied physiology · 2024Article
- Effects of exercise timing and intensity on physiological circadian rhythm and sleep quality: a systematic review.Physical activity and nutrition · 2023Article
- Exergames improves cognitive functions in adolescents with depression: study protocol of a prospective, assessor-blind, randomized controlled trial.BMC psychiatry · 2023Article
- Intervention Effect of Long-Term Aerobic Training on Anxiety, Depression, and Sleep Quality of Middle School Students With Depression After COVID-19.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
(1) Background: While the antidepressant effects of aerobic exercise (AE) are well documented, fewer studies have examined impact of AE as an add-on treatment. Moreover, various effects on neurobiological variables have been suggested. This study examines effects of AE on Cortisol Awakening Reaction (CAR), serum Brain Derived Neurotrophic Factor (sBDNF), Tumor Necrosis Factor alpha (TNF-alpha) and sleep. (2) Methods: Inpatients with moderate-to-severe depression (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.