Evidence map›Paper›PMID 33805026›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Nestin Expression Is Associated with Relapses in Head and Neck Lesions.

Mario Pérez-Sayáns, Cintia M Chamorro-Petronacci, Fátima Baltazar, Fabio Ramoa Pires, Ángel Ínsua, Juan A Suárez-Quintanilla, José M Suárez-Peñaranda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Mario Pérez-SayánsOral Medicine, Oral Surgery and Implantology Unit (MedOralRes), Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0003-2196-9868
Cintia M Chamorro-PetronacciResearch Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.ORCID 0000-0002-5637-9908
Fátima BaltazarLife and Health Science Research Institute (ICVS), School of Medicine University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-1770-4544
Fabio Ramoa PiresPost-Graduation Program in Dentistry, Department of Oral Pathology, Estácio de Sá University, State University of Rio de Janeiro, Rio de Janeiro 22631-000, Brazil.
Ángel ÍnsuaDepartment of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109-1078, USA.
Juan A Suárez-QuintanillaArea of Human Anatomy and Embryology, Faculty of Medicine and Dentistry, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
José M Suárez-PeñarandaPathological Anatomy Service, University Hospital Complex of Santiago (CHUS), 15706 Santiago de Compostela, Spain.ORCID 0000-0003-4033-3638
Universidade de Santiago de Compostela · ESInstituto de Investigación Sanitaria de Santiago · ESUniversidade do Estado do Rio de Janeiro · BRUniversity of Michigan · USUniversity of Minho · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim was to investigate the clinical significance of nestin immunohistochemical expression in head and neck area lesions and to study its role in patient survival and recurrence.

methods39 (44.3%) nasosinus, 37 (42%) major salivary gland (6 submandibular and 31 parotid) and 12 (13.6%) oral cavity lesions of paraffin-embedded samples were retrospectively included.

resultsThe expression was categorized into grades, negative for 55 (62.5%) cases, grade 1 in 10 cases (11.4%), grade 2 in 12 cases (13.6%), and grade 3 in 11 cases (12.5%); 100% of pleomorphic adenomas were positive for nestin with grade 3 intensity, 100% of polyps and inverted papillomas were negative (

conclusionsNestin could be a useful marker to detect the presence of stem cells in head and neck tumors that have a role in tumor initiation and progression.

Indexed as

head and neck neoplasmsimmunohistochemistrynestinrecurrence

Identifiers

PMID33805026
PMCPMC8063927
OpenAlexW3137426703

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.