Evidence map›Paper›PMID 33804979›Full record

ReviewCancers2021

New Insights into Endometrial Cancer.

Laura Paleari, Silvia Pesce, Mariangela Rutigliani, Marco Greppi, Valentina Obino, Franco Gorlero, Valerio Gaetano Vellone, Emanuela Marcenaro

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Review
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  19. Article
  20. New Strategies for Endometrial Cancer Detection and Management.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Laura PaleariA.Li.Sa., Liguria Region Health Authority, 16121 Genoa, Italy.ORCID 0000-0002-6176-2979
Silvia PesceDepartment of Experimental Medicine and Centre of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-9798-4944
Mariangela RutiglianiPathology Unit, Galliera Hospital, 16128 Genoa, Italy.
Marco GreppiDepartment of Experimental Medicine and Centre of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, Italy.
Valentina ObinoDepartment of Experimental Medicine and Centre of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, Italy.
Franco GorleroObstetrics and Gynecology Unit, Galliera Hospital, 16128 Genoa, Italy.
Valerio Gaetano VellonePathology University Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0002-5107-1584
Emanuela MarcenaroDepartment of Experimental Medicine and Centre of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-4103-7566
University of Genoa · ITEnte Ospedaliero Ospedali Galliera · ITAgenzia Regionale per la Protezione dell'ambiente ligure · ITOspedale Policlinico San Martino · IT

Funding

Associazione Italiana per la Ricerca sul Cancro AIRC 5 × 1000-21147Compagnia di San Paolo 2019.866
6 · The paper itself

Abstract

EC is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors, such as aging and obesity, tends to become a public health issue. Although EC is a hormone-dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. Furthermore, its immune environment has been slightly characterized, but recent evidences point out how EC microenvironment may increase self-tolerance by reducing the recruitment of cytotoxic immune cells to the tumor site and/or modifying their phenotype, making these cells no longer able to suppress tumor growth. Here we highlight insights for EC management from diagnosis to a desirable trend of personalized treatment.

Indexed as

endometrial cancerhormone therapyimmune checkpoint inhibitorsmolecular classificationNatural Killer cellssteroid receptors

Identifiers

PMID33804979
PMCPMC8037936
OpenAlexW3135929032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.