Evidence map›Paper›PMID 33804861›Full record

ArticleInternational journal of molecular sciences2021

Possibility for Transcriptional Targeting of Cancer-Associated Fibroblasts-Limitations and Opportunities.

Dina V Antonova, Marina V Zinovyeva, Liya G Kondratyeva, Alexander V Sass, Irina V Alekseenko, Victor V Pleshkan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Efficiency of Promoters of Human GenesInternational journal of molecular sciences · 2023
    Article
  5. Cell-specific expression of theFrontiers in molecular biosciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dina V AntonovaDepartment of Genomics and Postgenomic Technologies, Gene Immunooncotherapy Group, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Marina V ZinovyevaDepartment of Genomics and Postgenomic Technologies, Gene Immunooncotherapy Group, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Liya G KondratyevaDepartment of Genomics and Postgenomic Technologies, Gene Immunooncotherapy Group, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.ORCID 0000-0003-3990-8262
Alexander V SassDepartment of Genomics and Postgenomic Technologies, Gene Immunooncotherapy Group, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Irina V AlekseenkoDepartment of Genomics and Postgenomic Technologies, Gene Immunooncotherapy Group, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Victor V PleshkanDepartment of Genomics and Postgenomic Technologies, Gene Immunooncotherapy Group, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.ORCID 0000-0001-5456-5582
Institute of Bioorganic Chemistry · RUKurchatov Institute · RU

Funding

Russian Foundation for Basic Research 15-04-07773(a)
6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAF) are attractive therapeutic targets in the tumor microenvironment. The possibility of using CAFs as a source of therapeutic molecules is a challenging approach in gene therapy. This requires transcriptional targeting of transgene expression by cis-regulatory elements (CRE). Little is known about which CREs can provide selective transgene expression in CAFs. We hypothesized that the promoters of

Indexed as

Promoter Regions, GeneticTransgenesAnimalsCancer-Associated FibroblastsCell Line, TumorChemokine CXCL12Connective Tissue Growth FactorEndopeptidasesFibroblast Activation Protein AlphaGelatinasesHumansHuman Umbilical Vein Endothelial CellsInsulin-Like Growth Factor Binding Protein 2Jagged-1 ProteinMembrane ProteinsMiceCCN2 protein, humanChemokine CXCL12Connective Tissue Growth FactorCXCL12 protein, humanEndopeptidasesFibroblast Activation Protein AlphaGelatinasesIGFBP2 protein, humanInsulin-Like Growth Factor Binding Protein 2JAG1 protein, humanJagged-1 ProteinMembrane ProteinsOsteonectinSerine EndopeptidasesSNAI1 protein, humanSnail Family Transcription FactorsSPARC protein, humanfibroblastsgene therapypromotertranscriptional targetingtumor microenvironment

Identifiers

PMID33804861
PMCPMC8038081
OpenAlexW3148747746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.