ReviewChildren (Basel, Switzerland)2021
The Role of Sleep in the Transition from Acute to Chronic Musculoskeletal Pain in Youth-A Narrative Review.
Review in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of psychological interventions on sleep in children and adolescents with chronic pain: a systematic review with meta-analysis of randomized controlled trials.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Pooled it
- The association between sleep quality and postoperative pain after half-impacted mandibular third molar extraction: comparison of three statistical models.BMC oral health · 2026Article
- Relationships between orofacial pain and sleep: Analysis of UK biobank and genome-wide association studies data.Journal of dental sciences · 2025Article
- Influence of self-reported physical exercise on musculoskeletal pain among Chinese medical students.Scientific reports · 2024Article
- A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress.Journal of pain research · 2024Review
- Bidirectional relationship between pain and sleep disturbance in middle-aged and older adults: evidence from the China health and retirement longitudinal study.Frontiers in psychiatry · 2024Article
- The complexities of the sleep-pain relationship in adolescents: A critical review.Sleep medicine reviews · 2023Review
- Associations among acute and chronic musculoskeletal pain, sleep duration, and C-reactive protein (CRP): A cross-sectional study of the UK biobank dataset.Sleep medicine · 2023Article
- Prevention is better than cure: why early interventions for insomnia and chronic pain during adolescence should be a priority.Frontiers in psychology · 2023Article
- Predictors of pain persistence and disability in high-school students with chronic neck pain at 6-month follow-up.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Identifying and Managing Suicidality in Children and Adolescents with Chronic Pain: Evidence-Based Treatment Strategies.Psychology research and behavior management · 2022Review
- Temporal Daily Relationships Between Sleep and Pain in Adolescents With Systemic Lupus Erythematosus.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Musculoskeletal pain is common in the general pediatric population and is a challenge to youth, their parents, and society. The majority of children experiencing musculoskeletal pain will recover; however, a small subgroup of youth develops chronic pain. There is limited understanding of the factors that affect the transition from acute to chronic pain in youth. This review introduces sleep deficiency in the acute to chronic pain transition, exploring the potential mediational or mechanistic role and pathways of sleep in this process, including the interaction with sensory, psychological, and social components of pain and highlighting new avenues for treatment. Biological mechanisms include the increased production of inflammatory mediators and the effect on the hypothalamus-pituitary-adrenal (HPA) axis and on the dopaminergic signaling. Psychological and social components include the effect of sleep on the emotional-affective and behavioral components of pain, the negative impact on daily and social activities and coping strategies and on the reward system, increased pain catastrophizing, fear of pain, pain-related anxiety, hypervigilance, and social isolation. Future longitudinal studies are needed to elucidate these mechanistic pathways of the effect of sleep on the transition from acute to chronic pain, which may lead to the development of new treatment targets to prevent this transition.
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Registered trials
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