Evidence map›Paper›PMID 33804739›Full record

ReviewInternational journal of molecular sciences2021

A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption.

Mahmoud Mona, Zunnaira Abbasi, Firas Kobeissy, Abdulrahman Chahbandar, Roberta Pileggi

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. [Research progress on external cervical resorption].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Review
  3. Article
  4. Review
  5. Influence of Cone-Beam Computed Tomography Voxel Sizes in the Detection of Chemically Induced External Root Resorptions.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mahmoud MonaDepartment of Endodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA.ORCID 0000-0002-2626-8318
Zunnaira AbbasiDepartment of Endodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
Firas KobeissyDepartment of Emergency Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-5008-6944
Abdulrahman ChahbandarDepartment of Endodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
Roberta PileggiDepartment of Endodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

External root resorption (ERR) is a silent destructive phenomenon detrimental to dental health. ERR may have multiple etiologies such as infection, inflammation, traumatic injuries, pressure, mechanical stimulations, neoplastic conditions, systemic disorders, or idiopathic causes. Often, if undiagnosed and untreated, ERR can lead to the loss of the tooth or multiple teeth. Traditionally, clinicians have relied on radiographs and cone beam computed tomography (CBCT) images for the diagnosis of ERR; however, these techniques are not often precise or definitive and may require exposure of patients to more ionizing radiation than necessary. To overcome these shortcomings, there is an immense need to develop non-invasive approaches such as biomarker screening methods for rapid and precise diagnosis for ERR. In this review, we performed a literature survey for potential salivary or gingival crevicular fluid (GCF) proteomic biomarkers associated with ERR and analyzed the potential pathways leading to ERR. To the best of our knowledge, this is the first proteomics biomarker survey that connects ERR to body biofluids which represents a novel approach to diagnose and even monitor treatment progress for ERR.

Indexed as

BiomarkersProteomicsComputational BiologyDisease ManagementDisease SusceptibilityGingival Crevicular FluidHumansRadiographyRoot ResorptionSignal TransductionSystems BiologyBiomarkersdental trauma and biomarkersdentin matrix acidic phosphoprotein 1dentin phosphoproteinsdentin sialophosphoproteindentin sialoproteinexternal root resorptioninvasive cervical resorption

Identifiers

PMID33804739
PMCPMC8003910
OpenAlexW3139388430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.