Evidence map›Paper›PMID 33804705›Full record

ArticlePharmaceutics2021

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals.

Steven A Ross, Andrew P Hurt, Milan Antonijevic, Nicolaos Bouropoulos, Adam Ward, Pat Basford, Mark McAllister, Dennis Douroumis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Steven A RossFaculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.
Andrew P HurtFaculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.
Milan AntonijevicFaculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.ORCID 0000-0002-5847-7886
Nicolaos BouropoulosDepartment of Materials Science, University of Patras, Rio, 26504 Patras, Greece.ORCID 0000-0002-3922-7515
Adam WardDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, West Yorkshire HD1 3DH, UK.
Pat BasfordPfizer Global Research & Development, Ramsgate Road, Sandwich CT13 9NJ, UK.
Mark McAllisterPfizer Global Research & Development, Ramsgate Road, Sandwich CT13 9NJ, UK.
Dennis DouroumisFaculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.ORCID 0000-0002-3782-0091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was the manufacturing and scale-up of theophylline-nicotinamide (THL-NIC) pharmaceutical cocrystals processed by hot-melt extrusion (HME). The barrel temperature profile, feed rate and screw speed were found to be the critical processing parameters with a residence time of approximately 47 s for the scaled-up batches. Physicochemical characterization using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction of bulk and extruded materials revealed the formation of high purity cocrystals (98.6%). The quality of THL-NIC remained unchanged under accelerated stability conditions.

Indexed as

cocrystalscontinuous manufacturinghot-melt extrusionRietveld refinementscale-upsolubilitystabilitysurface dissolution imagingX-ray

Identifiers

PMID33804705
PMCPMC8004052

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.