Evidence map›Paper›PMID 33804655›Full record

ArticleCancers2021

Efficacy of Targeted Radionuclide Therapy Using [

Hussein Akil, Mercedes Quintana, Jérémy H Raymond, Tommy Billoux, Valentin Benboubker, Sophie Besse, Philippe Auzeloux, Véronique Delmas, Valérie Petit, Lionel Larue and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Integrated approaches to sensitizing melanoma to radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Targeting Melanin in Melanoma with Radionuclide Therapy.International journal of molecular sciences · 2022
    Review
  8. Phase I study of [BMC cancer · 2022
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hussein AkilINSERM U1240, University of Clermont Auvergne, 58 rue Montalembert, 63000 Clermont-Ferrand, France.ORCID 0000-0002-8177-6833
Mercedes QuintanaINSERM U1240, University of Clermont Auvergne, 58 rue Montalembert, 63000 Clermont-Ferrand, France.
Jérémy H RaymondINSERM U1021, Normal and Pathological Development of Melanocytes, Institut Curie, PSL Research University, Campus Universitaire, 91898 Orsay, France.ORCID 0000-0002-8712-895X
Tommy BillouxCirmen, Centre Jean Perrin, 58 rue Montalembert, 63000 Clermont-Ferrand, France.ORCID 0000-0003-3610-3709
Valentin BenboubkerINSERM U1240, University of Clermont Auvergne, 58 rue Montalembert, 63000 Clermont-Ferrand, France.ORCID 0000-0003-3162-1128
Sophie BesseINSERM U1240, University of Clermont Auvergne, 58 rue Montalembert, 63000 Clermont-Ferrand, France.ORCID 0000-0002-9842-9002
Philippe AuzelouxINSERM U1240, University of Clermont Auvergne, 58 rue Montalembert, 63000 Clermont-Ferrand, France.
Véronique DelmasINSERM U1021, Normal and Pathological Development of Melanocytes, Institut Curie, PSL Research University, Campus Universitaire, 91898 Orsay, France.ORCID 0000-0001-7368-3664
Valérie PetitINSERM U1021, Normal and Pathological Development of Melanocytes, Institut Curie, PSL Research University, Campus Universitaire, 91898 Orsay, France.
Lionel LarueINSERM U1021, Normal and Pathological Development of Melanocytes, Institut Curie, PSL Research University, Campus Universitaire, 91898 Orsay, France.
Michel D'IncanINSERM U1240, University of Clermont Auvergne, 58 rue Montalembert, 63000 Clermont-Ferrand, France.ORCID 0000-0002-6367-4227
Françoise DegoulINSERM U1240, University of Clermont Auvergne, 58 rue Montalembert, 63000 Clermont-Ferrand, France.ORCID 0000-0002-0206-3350
Jacques RouanetINSERM U1240, University of Clermont Auvergne, 58 rue Montalembert, 63000 Clermont-Ferrand, France.ORCID 0000-0002-5821-0786
Centre National de la Recherche Scientifique · FRInserm · FRCentre Jean Perrin · FR

Funding

Association Instituts Carnot No numberCentre National de la Recherche Scientifique No numberConseil Régional d'Auvergne No numberFondation ARC pour la Recherche sur le Cancer No numberInstitut National de la Santé et de la Recherche Médicale No numberInstitut National Du Cancer No numberITMO Cancer No numberLigue Contre le Cancer No numberSociété Française de Dermatologie et de Pathologie Sexuellement Transmissible No numberUniversité Clermont-Auvergne No number
6 · The paper itself

Abstract

purposeTo assess the efficiency of targeted radionuclide therapy (TRT), alone or in combination with MEK inhibitors (MEKi), in melanomas harboring constitutive MAPK/ERK activation responsible for tumor radioresistance.

methodsFor TRT, we used a melanin radiotracer ([

resultsTRT cooperated with MEKi to increase apoptosis in both BRAF- and NRAS-mutant spheroids. NRAS

conclusionOur data suggest that [

Indexed as

BRAF mutationMEK inhibitorsmelanoma spheroid modelNRAS mutationtargeted radionuclide therapy

Identifiers

PMID33804655
PMCPMC8003594
OpenAlexW3136961096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.