Fetal Macrophages Exposed to

Jeng-Chang Chen, Liang-Shiou Ou, Ming-Ling Kuo, Li-Yun Tseng, Hsueh-Ling Chang, Shiang-Chi Chen, Cheng-Hsun Chiu

Abstract read

In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

The vertical transmission ofOne health (Amsterdam, Netherlands) · 2023
Review
Immunological Consequences ofFrontiers in immunology · 2021
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeng-Chang ChenDepartment of Surgery, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-7776-4338

Liang-Shiou OuDivision of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

Ming-Ling KuoDivision of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

Li-Yun TsengPediatric Research Center, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

Hsueh-Ling ChangPediatric Research Center, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

Shiang-Chi ChenDepartment of Nursing, Taipei Medical University, Taipei 110, Taiwan.

Cheng-Hsun ChiuDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

Funding

Chang Gung Memorial Hospital, Taiwan CMRPG3G1501-3 & CMRPG3E0491-3

6 · The paper itself

Abstract

Despite the evidence for fetal immunization following maternal infection, it remained a mystery how the fetal immune system was primed by vertically-transmitted pathogens or microbial antigens, especially before its full maturation. We previously demonstrated the capacity of fetal macrophages for endocytosing oncoprotein and allergens to bridge towards adaptive immunity in postnatal life. To investigate the immunological consequences of fetal contact with microbial antigens and the role of fetal macrophages in the defense against infection before T-cell development, we exposed gestational day 14 murine fetuses and their macrophages to flagellin and heat-killed

Indexed as

fetal immunizationmacrophagematernal infectionSalmonellavertical transmission

Identifiers

PMID33804435

DOI10.3390/biomedicines9030245

PMCPMC8001423

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.