Evidence map›Paper›PMID 33804401›Full record

ArticleMetabolites2021

Quantitative Assessment of Occipital Metabolic and Energetic Changes in Parkinson's Patients, Using In Vivo

Xiao-Hong Zhu, Byeong-Yeul Lee, Paul Tuite, Lisa Coles, Abhishek G Sathe, Chi Chen, Jim Cloyd, Walter C Low, Clifford J Steer, Wei Chen

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Detecting the Stage of Fibrosis in Non-alcoholic Fatty Liver Disease by 9.4T Phosphorus Magnetic Resonance Spectroscopy.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. ATP and NADNutrients · 2023
    Article
  12. Value of MRS combined with DTI in evaluating brain development of infants aged from 2 months to 2 years old.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiao-Hong ZhuCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA.
Byeong-Yeul LeeCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-1928-0455
Paul TuiteDepartment of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-1413-7924
Lisa ColesDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Abhishek G SatheDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-7348-4208
Chi ChenDepartment of Food Science and Nutrition, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9703-604X
Jim CloydDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-3607-6619
Walter C LowDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9703-604X
Clifford J SteerDepartments of Medicine and Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Wei ChenCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA.
University of Minnesota · US

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
Breaking Spatiotemporal Barriers of MR Imaging Technologies to Study Human Brain Function and NeuroenergeticsU01EB026978 · NIBIB · UNIVERSITY OF MINNESOTA · PI CHEN, WEI, ZHU, XIAO-HONG · 2018 to 2022
$6.4M
Integrated fMRI Methods to Study Neurophysiology and Circuit Dynamics at Laminar and Columnar LevelR01MH111413 · NIMH · UNIVERSITY OF MINNESOTA · PI CHEN, WEI · 2016 to 2020
$4.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Development of Quantitative Deuterium MRS Imaging for Human Brain Tumor Application at Ultrahigh FieldR01CA240953 · NCI · UNIVERSITY OF MINNESOTA · PI CHEN, WEI, LIANG, ZHI-PEI · 2019 to 2025
$2.7M
Advancing simultaneous fMRI-multiphoton imaging technique to study brain function and connectivity across different scales at ultrahigh fieldR01NS118330 · NINDS · UNIVERSITY OF MINNESOTA · PI CHEN, WEI, CUI, MENG · 2020 to 2024
$2.7M
NCI NIH HHS R01 CA240953NIBIB NIH HHS P41 EB027061NIBIB NIH HHS U01 EB026978NIH HHS R01 MH111413, R01 CA240953, R01 NS118330, U01 EB026978, P41 EB027061, P30 NS076408NIMH NIH HHS R01 MH111413NINDS NIH HHS P30 NS076408NINDS NIH HHS R01 NS118330University of Minnesota Academic Health Center Faculty Research Development GrantUniversity of Minnesota Foundation N/A
6 · The paper itself

Abstract

Abnormal energy metabolism associated with mitochondrial dysfunction is thought to be a major contributor to the progression of neurodegenerative diseases such as Parkinson's disease (PD). Recent advancements in the field of magnetic resonance (MR) based metabolic imaging provide state-of-the-art technologies for non-invasively probing cerebral energy metabolism under various brain conditions. In this proof-of-principle clinical study, we employed quantitative

Indexed as

cerebral ATP energy metabolismhuman brainin vivo 31P MRS-based metabolic imagingneurodegenerative diseaseursodeoxycholic acid (UDCA)

Identifiers

PMID33804401
PMCPMC8000945
OpenAlexW3134856384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.