Evidence map›Paper›PMID 33804319›Full record

ArticleJournal of clinical medicine2021

CPAP Therapy Termination Rates by OSA Phenotype: A French Nationwide Database Analysis.

Jean-Louis Pépin, Sébastien Bailly, Pierre Rinder, Dan Adler, Daniel Szeftel, Atul Malhotra, Peter A Cistulli, Adam Benjafield, Florent Lavergne, Anne Josseran and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07530302 (Treatment Failure of Continuous Positive Airway Pressure), which is not on this map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07530302 narecruitingnot on this mapstarted 2026, after this paper: background citation

Treatment Failure of Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea Syndrome (OSA): A Randomized Controlled Trial Comparing Polysomnography and the Sunrise Device to Drive Treatment-Adjustment Decisions.

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2026 to 2029Enrolled105ConditionsSleep Apnea Syndrome, ObstructiveArmsSunrise
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 147 citations in OpenAlex.

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  14. Solid waste production by CPAP treatment in the United States.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
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  18. A new method using pointing area diagrams to characterize and compare ventilation masks used in continuous positive airway pressure treatment for apneic patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Jean-Louis PépinHP2 Laboratory, University Grenoble Alpes, Inserm, CHU Grenoble Alpes, 38043 Grenoble, France.
Sébastien BaillyHP2 Laboratory, University Grenoble Alpes, Inserm, CHU Grenoble Alpes, 38043 Grenoble, France.ORCID 0000-0002-2179-4650
Pierre RinderSEMEIA, 75010 Paris, France.
Dan AdlerFaculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.ORCID 0000-0002-9915-862X
Daniel SzeftelSEMEIA, 75010 Paris, France.
Atul MalhotraPulmonary, Critical Care and Sleep Medicine, University of California, San Diego, CA 92037, USA.
Peter A CistulliCharles Perkins Centre, Faculty of Medicine and Health, University Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-7920-4924
Adam BenjafieldResMed Science Center, Sydney, NSW 2153, Australia.
Florent LavergneResMed Science Center, 69791 Saint Priest, France.ORCID 0000-0002-8624-5900
Anne JosseranResMed Science Center, 69791 Saint Priest, France.
Renaud TamisierHP2 Laboratory, University Grenoble Alpes, Inserm, CHU Grenoble Alpes, 38043 Grenoble, France.
Pierre HornusSEMEIA, 75010 Paris, France.
On Behalf Of The medXcloud Group
Inserm · FRScience et Médecine (France) · FRSurgiMedia (France) · FRResMed (Australia) · AUThe University of Sydney · AUUniversity of California System · USUniversity of Geneva · CH

Funding

ResMed unrestricted grantUniversité Grenoble Alpes ANR-19-P3IA-0003
6 · The paper itself

Abstract

The nationwide claims data lake for sleep apnoea (ALASKA)-real-life data for understanding and increasing obstructive sleep apnea (OSA) quality of care study-investigated long-term continuous positive airway pressure (CPAP) termination rates, focusing on the contribution of comorbidities. The French national health insurance reimbursement system data for new CPAP users aged ≥18 years were analyzed. Innovative algorithms were used to determine the presence of specific comorbidities (hypertension, diabetes and chronic obstructive pulmonary disease (COPD)). Therapy termination was defined as cessation of CPAP reimbursements. A total of 480,000 patients were included (mean age 59.3 ± 13.6 years, 65.4% male). An amount of 50.7, 24.4 and 4.3% of patients, respectively, had hypertension, diabetes and COPD. Overall CPAP termination rates after 1, 2 and 3 years were 23.1, 37.1 and 47.7%, respectively. On multivariable analysis, age categories, female sex (1.09 (1.08-1.10) and COPD (1.12 (1.10-1.13)) and diabetes (1.18 (1.16-1.19)) were significantly associated with higher CPAP termination risk; patients with hypertension were more likely to continue using CPAP (hazard ratio 0.96 (95% confidence interval 0.95-0.97)). Therapy termination rates were highest in younger or older patients with ≥1 comorbidity. Comorbidities have an important influence on long-term CPAP continuation in patients with OSA.

Indexed as

adherencecomorbiditiescontinuous positive airway pressureobstructive sleep apneatreatment

Identifiers

PMID33804319
PMCPMC7957656
OpenAlexW3134953171

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.