Distinct Somatic Alteration Features Identified by Gene Panel Sequencing in Korean Triple-Negative Breast Cancer with High Ki67 Expression.

Woo Young Sun, Jina Lee, Bong Kyun Kim, Jong Ok Kim, Joonhong Park

Open access · goldAbstract read

In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 64% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Neoantigen-Driven Immunotherapy in Triple-Negative Breast Cancer: Emerging Strategies and Clinical Potential.Biomedicines · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Woo Young SunDepartment of Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0002-5447-4266

Jina LeeDepartment of Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Bong Kyun KimDepartment of Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0002-3845-9584

Jong Ok KimDepartment of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Joonhong ParkDepartment of Laboratory Medicine, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Korea.ORCID 0000-0001-7354-4234

Catholic University of Korea · KRJeonbuk National University Hospital · KR

Funding

Clinical research institute Grant funded by The Catholic University of Korea Daejeon St. Mary's Hospital CMCDJ-P-2019-001

6 · The paper itself

Abstract

This study aimed to clarify the genetic difference between Korean triple-negative breast cancer (TNBC) and other breast cancer (BC) subtypes. TNBC was defined as the absence of hormonal receptors and human epidermal growth factor receptor 2 (HER2) amplification. DNA panel of the Ion Torrent Oncomine Comprehensive Assay (OCA) v3 was performed to identify somatic alteration in 48 specimens. In a total of 102 alterations (37 nonsense, 35 missense, 8 frameshift and 22 amplifications), 30 nucleotide alterations (24 nonsense, 1 missense, and 5 frameshift) were newly identified. The eight most commonly altered genes were

Indexed as

early detectiongene panel sequencingKi-67PIK3CATP53triple-negative breast cancer

Identifiers

PMID33804295

DOI10.3390/diagnostics11030416

PMCPMC8000916

OpenAlexW3134226102

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.