Evidence map›Paper›PMID 33804118›Full record

ArticleMolecules (Basel, Switzerland)2021

Intramolecular Nicholas Reaction Enables the Stereoselective Synthesis of Strained Cyclooctynes.

Diego M Monzón, Juan Manuel Betancort, Tomás Martín, Miguel Ángel Ramírez, Víctor S Martín, David Díaz Díaz

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Catalyst-Controlled Regiodivergent Oxidation of Unsymmetrical Diols.Journal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Diego M MonzónDepartamento de Química Orgánica, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
Juan Manuel BetancortInstituto de Bio-Orgánica Antonio González, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
Tomás MartínInstituto de Bio-Orgánica Antonio González, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
Miguel Ángel RamírezDepartamento de Química Orgánica, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
Víctor S MartínDepartamento de Química Orgánica, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
David Díaz DíazDepartamento de Química Orgánica, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.ORCID 0000-0002-0557-3364

Funding

Ministry of Economy and Competitiveness-MINECO CTQ2014-56362-C2-1-PSpanish MCIU/AEI PGC2018-094503-B-C21Spanish Ministry of Science and Innovation PID2019-105391GB-C21
6 · The paper itself

Abstract

Cyclic products can be obtained through the intramolecular version of the Nicholas reaction, which requires having the nucleophile connected to the alkyne unit. Here, we report the synthesis of 1-oxa-3-cyclooctynes starting from commercially available (1

Indexed as

cyclizationcyclooctyneNicholas reactionoxacyclepropargylic carbocationring strain

Identifiers

PMID33804118
PMCPMC7999112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.