Evidence map›Paper›PMID 33804077›Full record

ArticleVaccines2021

Protective Effect of Nasal Colonisation with

Elisa Ramos-Sevillano, Giuseppe Ercoli, José Afonso Guerra-Assunção, Philip Felgner, Rafael Ramiro de Assis, Rie Nakajima, David Goldblatt, Kevin Kweku Adjei Tetteh, Robert Simon Heyderman, Stephen Brian Gordon and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Human vaccines & immunotherapeutics · 2025
    Review
  4. Article
  5. Naturally acquired adaptive immunity toClinical & translational immunology · 2024
    Article
  6. Strain Specific Variations inFrontiers in immunology · 2022
    Article
  7. Non-capsular based immunization approaches to preventFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Elisa Ramos-SevillanoCentre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, Rayne Institute, London WC1E 6JF, UK.ORCID 0000-0003-0803-2755
Giuseppe ErcoliCentre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, Rayne Institute, London WC1E 6JF, UK.ORCID 0000-0001-7326-1680
José Afonso Guerra-AssunçãoGreat Ormond Street Institute of Child Health, University College London (UCL), London WC1N 1EH, UK.ORCID 0000-0001-6593-403X
Philip FelgnerVaccine Research and Development Center, Department of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697-4560, USA.
Rafael Ramiro de AssisVaccine Research and Development Center, Department of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697-4560, USA.
Rie NakajimaVaccine Research and Development Center, Department of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697-4560, USA.
David GoldblattImmunobiology Section, UCL Great Ormond Street Institute of Child Health, NIHR Biomedical Research Centre, London WC1N 1EH, UK.
Kevin Kweku Adjei TettehFaculty of Infectious and Tropical Diseases, London School of Tropical Medicine and Hygiene, London WC1E 7HT, UK.
Robert Simon HeydermanResearch Department of Infection, Division of Infection and Immunity, University College London, Rayne Institute, London WC1E 6JF, UK.ORCID 0000-0003-4573-449X
Stephen Brian GordonMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre 30096, Malawi.ORCID 0000-0001-6576-1116
Daniela Mulari FerreriaDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
Jeremy Stuart BrownCentre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, Rayne Institute, London WC1E 6JF, UK.ORCID 0000-0002-5650-5361
University College London · GBUniversity of California, Irvine · USLiverpool School of Tropical Medicine · GBUCL Biomedical Research Centre · GBUniversity of Liverpool · GBUniversity of London · GB

Funding

Medical Research Council MR/N02687X/1Medical Research Council MR/R001871/1Medical Research Council R/N02687X/1
6 · The paper itself

Abstract

rationaleNasopharyngeal administration of live virulence-attenuated

objectivesTo assess protective efficacy of nasopharyngeal administration of unencapsulated

methodsStrains containing MEASUREMENTS AND MAIN

resultsThe

conclusionsColonisation with the

Indexed as

capsulecolonisationimmunityproABCpsaAStreptococcus pneumoniaevaccine

Identifiers

PMID33804077
PMCPMC8000150
OpenAlexW3137508221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.