Evidence map›Paper›PMID 33804008›Full record

ReviewJournal of clinical medicine2021

Degenerative Cervical Myelopathy: Insights into Its Pathobiology and Molecular Mechanisms.

Ji Tu, Jose Vargas Castillo, Abhirup Das, Ashish D Diwan

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06664931 (Muscle Energy Versus Mulligan Techniques in Treating Patients With Cervical Spondylosis), which is not on this map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06664931 nacompletednot on this mapstarted 2024, after this paper: background citation

Muscle Energy Versus Mulligan Techniques in Treating Patients With Cervical Spondylosis

TypeinterventionalSponsorCairo UniversityRan2024 to 2025Enrolled40ConditionsCervical Spondylosis, Mulligan Mobilization, SNAGs, Muscle Energy TechniqueArmsGroup (A) Muscle Energy Technique (MET), Group (B) Mulligan Mobilizations Techniques (MMT).
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 74 citations in OpenAlex.

  1. Trial
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  7. Observational
  8. Review
  9. Article
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  13. Observational
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  15. Article
  16. T1 mapping using MP2RAGE in degenerative cervical myelopathy: a longitudinal study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ji TuSpine Labs, St. George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW 2217, Australia.ORCID 0000-0001-7933-3016
Jose Vargas CastilloSpine Service, St. George Hospital, Kogarah, NSW 2217, Australia.
Abhirup DasSpine Labs, St. George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW 2217, Australia.ORCID 0000-0003-1866-457X
Ashish D DiwanSpine Labs, St. George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW 2217, Australia.ORCID 0000-0003-1037-8421
Sutherland Hospital · AUSt George Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Degenerative cervical myelopathy (DCM), earlier referred to as cervical spondylotic myelopathy (CSM), is the most common and serious neurological disorder in the elderly population caused by chronic progressive compression or irritation of the spinal cord in the neck. The clinical features of DCM include localised neck pain and functional impairment of motor function in the arms, fingers and hands. If left untreated, this can lead to significant and permanent nerve damage including paralysis and death. Despite recent advancements in understanding the DCM pathology, prognosis remains poor and little is known about the molecular mechanisms underlying its pathogenesis. Moreover, there is scant evidence for the best treatment suitable for DCM patients. Decompressive surgery remains the most effective long-term treatment for this pathology, although the decision of when to perform such a procedure remains challenging. Given the fact that the aged population in the world is continuously increasing, DCM is posing a formidable challenge that needs urgent attention. Here, in this comprehensive review, we discuss the current knowledge of DCM pathology, including epidemiology, diagnosis, natural history, pathophysiology, risk factors, molecular features and treatment options. In addition to describing different scoring and classification systems used by clinicians in diagnosing DCM, we also highlight how advanced imaging techniques are being used to study the disease process. Last but not the least, we discuss several molecular underpinnings of DCM aetiology, including the cells involved and the pathways and molecules that are hallmarks of this disease.

Indexed as

blood-spinal cord barriercervical spondylotic myelopathy (CSM)degenerative cervical myelopathy (DCM)microbesneck painspinal cord compressionspinal cord disorder

Identifiers

PMID33804008
PMCPMC8001572
OpenAlexW3138439942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.