Evidence map›Paper›PMID 33803989›Full record

ArticleNanomaterials (Basel, Switzerland)2021

A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation.

Zhuo Chen, Zhinan Fu, Li Li, Enguang Ma, Xuhong Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhuo ChenState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.
Zhinan FuState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.
Li LiState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.
Enguang MaEngineering Research Center of Materials Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832000, China.
Xuhong GuoState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.ORCID 0000-0002-1792-8564

Funding

Key Scientific and Technological Project of Xinjiang Bingtuan 2018AB025NSFC Grants 51773061
6 · The paper itself

Abstract

Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up.

Indexed as

amphiphilic homopolymerchitosanflash nanoprecipitation (FNP)nanoparticle

Identifiers

PMID33803989
PMCPMC8001153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.