Evidence map›Paper›PMID 33803983›Full record

ArticleMolecules (Basel, Switzerland)2021

Assessing the Molecular Targets and Mode of Action of Furanone C-30 on

Victor Markus, Karina Golberg, Kerem Teralı, Nazmi Ozer, Esti Kramarsky-Winter, Robert S Marks, Ariel Kushmaro

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Anti-QS Strategies AgainstMicroorganisms · 2025
    Review
  8. Evolution of Resistant Mutants inMicroorganisms · 2025
    Article
  9. Article
  10. Biofilm · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Marine-Derived Furanones Targeting Quorum-Sensing Receptors inBioinformatics and biology insights · 2024
    Article
  16. Article
  17. Monitoring biofilm growth and dispersal in real-time with impedance biosensors.Journal of industrial microbiology & biotechnology · 2023
    Article
  18. Article
  19. Quorum sensing gene regulation inFrontiers in microbiology · 2023
    Article
  20. Anti-Quorum Sensing and Anti-Biofilm Activity ofMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Victor MarkusDepartment of Medical Biochemistry, Faculty of Medicine, Near East University, Nicosia 99138, Cyprus.ORCID 0000-0001-8727-4917
Karina GolbergAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.
Kerem TeralıDepartment of Medical Biochemistry, Faculty of Medicine, Near East University, Nicosia 99138, Cyprus.ORCID 0000-0002-9964-6383
Nazmi OzerDepartment of Biochemistry, Faculty of Pharmacy, Girne American University, Kyrenia 99428, Cyprus.
Esti Kramarsky-WinterAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.
Robert S MarksAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.ORCID 0000-0002-9697-3805
Ariel KushmaroAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.ORCID 0000-0002-1970-9656
Ben-Gurion University of the Negev · ILGirne American University · CYNear East University · CY

Funding

VM received funding from the Israeli Council for Higher Education (ICHE) and support from Near East University (NEU). xxxx
6 · The paper itself

Abstract

Quorum sensing (QS), a sophisticated system of bacterial communication that depends on population density, is employed by many pathogenic bacteria to regulate virulence. In view of the current reality of antibiotic resistance, it is expected that interfering with QS can address bacterial pathogenicity without stimulating the incidence of resistance. Thus, harnessing QS inhibitors has been considered a promising approach to overriding bacterial infections and combating antibiotic resistance that has become a major threat to public healthcare around the globe.

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBiofilmsDrug Resistance, MicrobialFuransPseudomonas aeruginosaQuorum SensingVirulenceAnti-Bacterial AgentsBacterial Proteinsfuranone C-30Furansfuranone C-30halogenated acyl-furanoneLasR proteinPseudomonas aeruginosaRhlR protein

Identifiers

PMID33803983
PMCPMC7998126
OpenAlexW3138235143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.