Evidence map›Paper›PMID 33803981›Full record

ReviewInternational journal of molecular sciences2021

Epigenetic Changes in Neoplastic Mast Cells and Potential Impact in Mastocytosis.

Edyta Reszka, Ewa Jabłońska, Edyta Wieczorek, Peter Valent, Michel Arock, Gunnar Nilsson, Bogusław Nedoszytko, Marek Niedoszytko

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Epigenetic alterations in Myeloid Malignancies.Advances in experimental medicine and biology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Edyta ReszkaDepartment of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland.ORCID 0000-0003-2153-4864
Ewa JabłońskaDepartment of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland.ORCID 0000-0002-3946-3964
Edyta WieczorekDepartment of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland.
Peter ValentDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0456-5095
Michel ArockDepartment of Hematological Biology, Pitié-Sapêtrière Hospital, Sorbonne University, 75013 Paris, France.ORCID 0000-0002-3990-4408
Gunnar NilssonDivision of Immunology and Allergy, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, SE-171 76 Stockholm, Sweden.ORCID 0000-0001-6795-5512
Bogusław NedoszytkoDepartment of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-211 Gdansk, Poland.ORCID 0000-0002-6286-0693
Marek NiedoszytkoDepartment of Allergology, Medical University of Gdansk, 80-211 Gdansk, Poland.
Nofer Institute of Occupational Medicine · PLGdańsk Medical University · PLKarolinska University Hospital · SEMedical University of Vienna · ATSorbonne Université · FR

Funding

Austrian Science Fund FWF P 32470
6 · The paper itself

Abstract

Systemic mastocytosis (SM) is a hematologic neoplasm with abnormal accumulation of mast cells in various organ systems such as the bone marrow, other visceral organs and skin. So far, only little is known about epigenetic changes contributing to the pathogenesis of SM. In the current article, we provide an overview of epigenetic changes that may occur and be relevant to mastocytosis, including mutations in genes involved in epigenetic processes, such as

Indexed as

DioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AEpigenesis, GeneticHematologic NeoplasmsHumansMast CellsMastocytosis, SystemicMutationProto-Oncogene ProteinsRepressor ProteinsASXL1 protein, humanDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanProto-Oncogene ProteinsRepressor ProteinsTET2 protein, humandemethylating agentsDNA methylationDNMT3AepigeneticsmastocytosismicroRNATET2

Identifiers

PMID33803981
PMCPMC7999363
OpenAlexW3137649845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.