Evidence map›Paper›PMID 33803959›Full record

ReviewMedicina (Kaunas, Lithuania)2021

Natural Plant Extracts and Compounds for Rheumatoid Arthritis Therapy.

Xiangyu Zhao, Young-Rok Kim, Yunhui Min, Yaping Zhao, Kyoungtag Do, Young-Ok Son

Open access · goldAbstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Mechanistic Study of Yibi Decoction in Treating Rheumatoid ArthritisEndocrine, metabolic & immune disorders drug targets · 2026
    Article
  4. Machine learning reveals targets ofFrontiers in immunology · 2026
    Article
  5. Article
  6. Article
  7. The Therapeutic Effects ofAntioxidants (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Nutrients · 2023
    Article
  17. Article
  18. Article
  19. Gallic Acid Inhibits Mesaconitine-Activated TRPV1-Channel-Induced Cardiotoxicity.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xiangyu ZhaoInterdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Korea.
Young-Rok KimDepartment of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Korea.
Yunhui MinInterdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Korea.
Yaping ZhaoSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240, China.
Kyoungtag DoDepartment of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Korea.ORCID 0000-0001-5188-7295
Young-Ok SonInterdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Korea.ORCID 0000-0003-0154-4061
Jeju National University · KRShanghai Jiao Tong University · CN

Funding

Korea Basic Science Institute 2020R1A6C101A188National Research Foundation of Korea 2020R1A2C2004128
6 · The paper itself

Abstract

Natural plant extracts and compounds (NPECs), which originate from herbs or plants, have been used in the clinical treatment of rheumatoid arthritis (RA) for many years. Over the years, many scientists have carried out a series of studies on the treatment of RA by NPEC. They found a high quantity of active NPECs with broad application prospects. In view of various complex functions of these NPECs, exploring their potential as medicines for RA treatment will be beneficial for RA patients. Thus, to help advance the development of high-quality NPECs for RA, we herein aimed to review the research progress of NPECs in the treatment of RA in recent years. Our findings showed that, from the pharmacological perspective, natural plant extracts or mixed herbal compounds effectively regulate the immune system to alleviate RA by inhibiting pro-inflammatory cytokines. Further, individualized medication can be applied according to each patient's physical condition. However, the pathogenesis of RA and its immune mechanism has not been fully understood and requires further studies.

Indexed as

Arthritis, RheumatoidDrugs, Chinese HerbalCytokinesHumansPlant ExtractsCytokinesDrugs, Chinese HerbalPlant Extractsnatural plantrheumatoid arthritistherapy

Identifiers

PMID33803959
PMCPMC8001474
OpenAlexW3137588620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.