Evidence map›Paper›PMID 33803906›Full record

ArticleBiomolecules2021

A Molecular Modeling Approach to Identify Potential Antileishmanial Compounds Against the Cell Division Cycle (cdc)-2-Related Kinase 12 (CRK12) Receptor of

Emmanuel Broni, Samuel K Kwofie, Seth O Asiedu, Whelton A Miller, Michael D Wilson

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cheminformatics-Based Study Identifies Potential Ebola VP40 Inhibitors.International journal of molecular sciences · 2023
    Article
  6. InhibitingPharmaceuticals (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Current leishmaniasis drug discovery.RSC medicinal chemistry · 2022
    Review
  11. Homology Modeling,Frontiers in cellular and infection microbiology · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Molecular modelling andInformatics in medicine unlocked · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Emmanuel BroniDepartment of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, Legon, Accra LG 77, Ghana.ORCID 0000-0002-6793-7530
Samuel K KwofieDepartment of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, Legon, Accra LG 77, Ghana.ORCID 0000-0002-1093-1517
Seth O AsieduDepartment of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Legon, Accra LG 581, Ghana.ORCID 0000-0002-2585-1800
Whelton A MillerDepartment of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA.
Michael D WilsonDepartment of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Legon, Accra LG 581, Ghana.ORCID 0000-0002-6048-8509
University of Ghana · GHLoyola University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The huge burden of leishmaniasis caused by the trypanosomatid protozoan parasite

Indexed as

Amphotericin BAntiprotozoal AgentsBinding SitesCell CycleCyclin-Dependent Kinase 9HumansLeishmania donovaniMolecular Dynamics SimulationMorpholinesParomomycinPhosphorylcholineProtein Structure, SecondaryPyrazolesPyrimidinesAmphotericin BAntiprotozoal AgentsCyclin-Dependent Kinase 9GSK3186899miltefosineMorpholinesParomomycinPhosphorylcholinePyrazolesPyrimidinesCRK12Leishmania donovaniLeishmaniasisleishmanicidemolecular dockingmolecular dynamics simulationnatural products

Identifiers

PMID33803906
PMCPMC8003136
OpenAlexW3138447271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.