Evidence map›Paper›PMID 33803785›Full record

ArticleJournal of clinical medicine2021

Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis.

Jaromir Jarecki, Teresa Małecka-Massalska, Izabela Polkowska, Bartosz Potoczniak, Ewa Kosior-Jarecka, Imre Szerb, Ewa Tomaszewska, Martina Gutbier, Maciej Dobrzyński, Tomasz Blicharski

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jaromir JareckiDepartment of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0002-6866-3850
Teresa Małecka-MassalskaPhysiology Department, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0003-3384-0324
Izabela PolkowskaDepartment and Clinic of Animal Surgery, University of Life Sciences, 20-033 Lublin, Poland.
Bartosz PotoczniakDepartment of Orthopaedics and Traumatology, Regional Hospital in Chełm, 22-100 Chełm, Poland.ORCID 0000-0003-1979-6857
Ewa Kosior-JareckaDepartment of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, 20-079 Lublin, Poland.ORCID 0000-0002-5251-7998
Imre SzerbDepartment of Traumatology, Semmelweis University Budapest, 1085 Budapest, Hungary.
Ewa TomaszewskaAnimal Physiology, University of Life Sciences, Lublin, 20-033 Lublin, Poland.ORCID 0000-0002-7574-2653
Martina GutbierDepartment of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wrocław, Poland.
Maciej DobrzyńskiDepartment of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wrocław, Poland.ORCID 0000-0003-2368-1534
Tomasz BlicharskiDepartment of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0001-9747-8817
Medical University of Lublin · PLUniversity of Life Sciences in Lublin · PLWroclaw Medical University · PLSemmelweis University · HUState School of Higher Education in Chełm · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to assess levels of adiponectin (ACRP-30) and leptin in serum and synovial fluid (SF) of overweight females with primary gonarthrosis (GOA) and to look for their correlations with clinical status and the level of biochemical OA biomarkers: matrix metalloproteinase (MMP) 1, MMP-9 and tissue inhibitor of metalloproteinase (TIMP-1). The studied group consisted of 39 overweight females undergoing primary total knee arthroplasty as a result of GOA. The stage of GOA was evaluated according to Knee Society Score (KSS), Ahlbäck and Kellgren-Lawrence (K-L) scores. Peripheral blood and SF were obtained. Levels of selected biomarkers were assessed using ELISA kits. The mean level of ACRP-30 in serum valued were 8393.80 ng/mL and in SF, 774.33 ng/mL, the mean concentration of leptin in serum was 32,040.74 pg/mL and in SF, 27,332.12 pg/mL. Levels of leptin in serum and SF correlated with body mass index (BMI), (

Indexed as

adipokinefemalegonarthritisleptinmatrix metalloproteinasesobesitypathogenesis

Identifiers

PMID33803785
PMCPMC8003316
OpenAlexW3137395989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.