Evidence map›Paper›PMID 33803769›Full record

ArticleInternational journal of molecular sciences2021

Design and Synthesis of Ranitidine Analogs as Multi-Target Directed Ligands for the Treatment of Alzheimer's Disease.

Jie Gao, Chen Suo, Jui-Heng Tseng, Melissa A Moss, Alvin V Terry, James Chapman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. A Novel Cu(II)-Binding Peptide Identified by Phage Display Inhibits CuInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jie GaoDepartment of Clinical and Diagnostic Science, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chen SuoDepartment of Chemical Engineering and Biomedical Engineering, University of South Carolina, Columbia, SC 29208, USA.
Jui-Heng TsengDepartment of Chemical Engineering and Biomedical Engineering, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0002-9036-9121
Melissa A MossDepartment of Chemical Engineering and Biomedical Engineering, University of South Carolina, Columbia, SC 29208, USA.
Alvin V TerryDepartment of Pharmacology and Toxicology, Augusta University, Augusta, GA 30912, USA.
James ChapmanDepartment of Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC 29208, USA.
University of South Carolina · USAugusta University · USUniversity of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aggregation of amyloid β (Aβ) peptides and deposition of amyloid plaques are implicated in the pathogenesis of Alzheimer's disease (AD). Therefore, blocking Aβ aggregation with small molecules has been proposed as one therapeutic approach for AD. In the present study, a series of ranitidine analogs containing cyclic imide isosteres were synthesized and their inhibitory activities toward Aβ aggregation were evaluated using in vitro thioflavin T assays. The structure-activity relationship revealed that the 1,8-naphthalimide moiety provided profound inhibition of Aβ aggregation and structural modifications on the other parts of the parent molecule (compound

Indexed as

Drug DesignAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCattleCholinesterase InhibitorsImidesLigandsProtein AggregatesRanitidineAmyloid beta-PeptidesCholinesterase InhibitorsImidesLigandsProtein AggregatesRanitidineacetylcholinesteraseAlzheimer’s diseaseamyloid β (Aβ) aggregationmulti-target directed ligandsnaphthalimidethioflavin T

Identifiers

PMID33803769
PMCPMC8003314
OpenAlexW3139496103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.