Evidence map›Paper›PMID 33803592›Full record

ReviewJournal of personalized medicine2021

Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go.

Ruggero De Maria Marchiano, Gabriele Di Sante, Geny Piro, Carmine Carbone, Giampaolo Tortora, Luca Boldrini, Antonella Pietragalla, Gennaro Daniele, Maria Tredicine, Alfredo Cesario and 5 more

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
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  8. Sorting out and navigating uncertainty in precision medicine.History and philosophy of the life sciences · 2026
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  17. Allies not enemies-creating a more empathetic and uplifting patient experience through technology and art.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruggero De Maria MarchianoDepartment of Translational Medicine and Surgery, Section of General Pathology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Gabriele Di SanteDepartment of Translational Medicine and Surgery, Section of General Pathology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Geny PiroComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-3708-5397
Carmine CarboneComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Giampaolo TortoraComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Luca BoldriniComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-5631-1575
Antonella PietragallaComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0001-6232-0323
Gennaro DanieleComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Maria TredicineDepartment of Translational Medicine and Surgery, Section of General Pathology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Alfredo CesarioScientific Direction, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-4687-0709
Vincenzo ValentiniComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Daniela GalloComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-1918-1054
Gabriele BabiniComprehensive Cancer Center-Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Marika D'OriaScientific Direction, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-4253-8223
Giovanni ScambiaScientific Direction, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of Precision Medicine has globally revolutionized the approach of translational research suggesting a patient-centric vision with therapeutic choices driven by the identification of specific predictive biomarkers of response to avoid ineffective therapies and reduce adverse effects. The spread of "multi-omics" analysis and the use of sensors, together with the ability to acquire clinical, behavioral, and environmental information on a large scale, will allow the digitization of the state of health or disease of each person, and the creation of a global health management system capable of generating real-time knowledge and new opportunities for prevention and therapy in the individual person (high-definition medicine). Real world data-based translational applications represent a promising alternative to the traditional evidence-based medicine (EBM) approaches that are based on the use of randomized clinical trials to test the selected hypothesis. Multi-modality data integration is necessary for example in precision oncology where an Avatar interface allows several simulations in order to define the best therapeutic scheme for each cancer patient.

Indexed as

high-definition medicineomicspersonalized medicinePrecision Medicine

Identifiers

PMID33803592
PMCPMC8002976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.