ReviewAntioxidants (Basel, Switzerland)2021
The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications.
Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Comparative Efficacy of Coriander Seed Extract-Loaded Selenium Nanoparticles and DMSA in Restoring Antioxidant/Apoptotic Balance of Lead-Induced Hepatotoxicity.Cell biochemistry and biophysics · 2026Article
- Bacopa monniera: A Promising Phytotherapeutic Approach in Management of Diabetes-Related Complications.Phytotherapy research : PTR · 2026Review
- Foliar application of Aloe vera and date palm extracts as natural biostimulants enhances yield, nutrient status and essential oil of cumin (Cuminum cyminum L.).Scientific reports · 2026Article
- Bio-degradable electrospun nanofibers encompassing dioxidovanadium benzimidazole compounds as potential drug delivery systems for diabetes mellitus.RSC advances · 2026Article
- Pomegranate-derived nanovesicles as therapeutic agents for acute pancreatitis in a murine model: anti-inflammatory, antioxidant, and endocrine-protective properties.Extracellular vesicles and circulating nucleic acids · 2026Article
- Network Pharmacology and Optimization of β-Sitosterol-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design for Enhanced Solubility and Sustained Drug Release in Diabetes.Pharmaceutical nanotechnology · 2026Article
- Mitigating nickel-induced toxicity: the protective role of native probiotic strains on oxidative stress and inflammatory pathways in mice lung tissues.BMC pharmacology & toxicology · 2025Article
- Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High-Fat Diet Model in Rats.Comprehensive Physiology · 2025Article
- Article
- Trifolium pratense-Derived Exosome Improved Serum Biochemical Parameters and Pancreatic Genes in STZ-Induced Diabetic Rats.Endocrinology, diabetes & metabolism · 2025Article
- Anti-Diabetic and Antioxidant Effect Evaluation of Thai Shallot and Cha-Miang in Diabetic Rats.Biology · 2025Article
- Comparison of Cytotoxicity and Antioxidant, Antibacterial, and Anti-Inflammatory Activity of Aqueous and Ethanolic Extracts fromMolecules (Basel, Switzerland) · 2025Article
- Article
- Unveiling Pharmacological Promise ofScientifica · 2025Article
- Phytochemical Analysis and Multifaceted Biomedical Activities ofLife (Basel, Switzerland) · 2024Article
- Exploring the key role of DNA methylation as an epigenetic modulator in oxidative stress related islet cell injury in patients with type 2 diabetes mellitus: a review.Journal of diabetes and metabolic disorders · 2024Review
- Evaluation of the Antidiabetic Potential of Xanthone-Rich Extracts fromInternational journal of molecular sciences · 2024Article
- Cordyceps cicadae polysaccharides attenuate diabetic nephropathy via the miR-30a-3p/TRIM16 axis.Journal of diabetes investigation · 2024Article
- Extract ofAntioxidants (Basel, Switzerland) · 2024Article
- Identification of antidiabetic inhibitors fromSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Diabetes is a complex metabolic disorder resulting either from insulin resistance or an impaired insulin secretion. Prolonged elevated blood glucose concentration, the key clinical sign of diabetes, initiates an enhancement of reactive oxygen species derived from glucose autoxidation and glycosylation of proteins. Consequently, chronic oxidative stress overwhelms cellular endogenous antioxidant defenses and leads to the acute and long-standing structural and functional changes of macromolecules resulting in impaired cellular functioning, cell death and organ dysfunction. The oxidative stress provoked chain of pathological events over time cause diabetic complications such as nephropathy, peripheral neuropathy, cardiomyopathy, retinopathy, hypertension, and liver disease. Under diabetic conditions, accompanying genome/epigenome and metabolite markers alterations may also affect glucose homeostasis, pancreatic β-cells, muscle, liver, and adipose tissue. By providing deeper genetic/epigenetic insight of direct or indirect dietary effects, nutrigenomics offers a promising opportunity to improve the quality of life of diabetic patients. Natural plant extracts, or their naturally occurring compounds, were shown to be very proficient in the prevention and treatment of different pathologies associated with oxidative stress including diabetes and its complications. Considering that food intake is one of the crucial components in diabetes' prevalence, progression and complications, this review summarizes the effect of the major plant secondary metabolite and phytoconstituents on the antioxidant enzymes activity and gene expression under diabetic conditions.
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