Evidence map›Paper›PMID 33803570›Full record

ArticleCancers2021

Human Papillomavirus Oral- and Sero- Positivity in Fanconi Anemia.

Sharon L Sauter, Xue Zhang, Lindsey Romick-Rosendale, Susanne I Wells, Kasiani C Myers, Marion G Brusadelli, Charles B Poff, Darron R Brown, Gitika Panicker, Elizabeth R Unger and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Fanconi Anemia Pathway Genes Advance Cervical CancerFrontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Sharon L SauterCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0003-0767-4051
Xue ZhangCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Lindsey Romick-RosendaleCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Susanne I WellsCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Kasiani C MyersCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Marion G BrusadelliCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Charles B PoffCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Darron R BrownDivision of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Gitika PanickerNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Elizabeth R UngerNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.ORCID 0000-0002-2925-5635
Parinda A MehtaCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Jack BleesingCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Stella M DaviesCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Melinda Butsch KovacicCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Cincinnati Children's Hospital Medical Center · USCenters for Disease Control and Prevention · USIndiana University School of Medicine

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR026314 · NCRR · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2009 to 2011
$14.3M
Fanconi Anemia as a Model for Susceptibility to Human Papillomavirus InfectionR01HL108102 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BUTSCHKOVACIC, MELINDA SUE · 2011 to 2015
$1.9M
Center for Clinical and Translational Science, University of Cincinnati UL1-RR026314-01Cincinnati Children's Hospital-sponsored Translational Research Initiative Grant SWellsFanconi Anemia Research Fund PMehta SerologyFanconi Anemia Research Fund SWells HPVNCRR NIH HHS UL1 RR026314NHLBI NIH HHS R01 HL108102Research Innovation and Pilot Funding Award LRomick-Rosendale
6 · The paper itself

Abstract

High-risk human papillomavirus (HPV) is prevalent and known to cause 5% of all cancers worldwide. The rare, cancer prone Fanconi anemia (FA) population is characterized by a predisposition to both head and neck squamous cell carcinomas and gynecological cancers, but the role of HPV in these cancers remains unclear. Prompted by a patient-family advocacy organization, oral HPV and HPV serological studies were simultaneously undertaken. Oral DNA samples from 201 individuals with FA, 303 unaffected family members, and 107 unrelated controls were tested for 37 HPV types. Serum samples from 115 individuals with FA and 55 unrelated controls were tested for antibodies against 9 HPV types. Oral HPV prevalence was higher for individuals with FA (20%) versus their parents (13%;

Indexed as

Fanconi anemiahead and neck squamous cell carcinomaHPV vaccinehuman papillomavirusoral HPV positivityoropharyngeal cancerseropositivity

Identifiers

PMID33803570
PMCPMC8003090
OpenAlexW3139501779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.