Evidence map›Paper›PMID 33803557›Full record

ArticleInternational journal of molecular sciences2021

Glucocorticoid Receptor Antagonist Mifepristone Does Not Alter Innate Anxiety-Like Behavior in Genetically-Selected Marchigian Sardinian (msP) Rats.

Valentina Vozella, Bryan Cruz, Luis A Natividad, Federica Benvenuti, Nazzareno Cannella, Scott Edwards, Eric P Zorrilla, Roberto Ciccocioppo, Marisa Roberto

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
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  5. Review
  6. Article
  7. Mifepristone decreases nicotine intake in dependent and non-dependent adult rats.Journal of psychopharmacology (Oxford, England) · 2024
    Article
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Valentina VozellaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-6868-3424
Bryan CruzDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-7418-1524
Luis A NatividadCollege of Pharmacy, The University of Austin, Austin, TX 78712, USA.
Federica BenvenutiSchool of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Italy.
Nazzareno CannellaSchool of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Italy.
Scott EdwardsDepartment of Physiology, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA.
Eric P ZorrillaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-2288-7899
Roberto CiccocioppoSchool of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0003-3126-9240
Marisa RobertoDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Research Institute · USUniversità di Camerino · ITLouisiana State University Health Sciences Center New Orleans · US

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI AMANDA J ROBERTS · 2003 to 2026
$46.3M
Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI RIVIER, CATHERINE L · 1985 to 2002
$5.1M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Neuroimmune mechanisms in stress and alcohol comorbidityR01AA027700 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2019 to 2023
$2.4M
Dorsal striatal phosphodiesterase 10A and compulsive ethanol useR01AA028879 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ZORRILLA, ERIC P · 2021 to 2025
$2.1M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
Vasopressin Signaling in Pain and Alcohol DependenceR01AA025996 · NIAAA · LSU HEALTH SCIENCES CENTER · PI EDWARDS, SCOTT · 2018 to 2022
$1.7M
Identification of novel mechanisms in alcohol-induced cognitive dysfunctionR00AA025393 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI NATIVIDAD, LUIS ALBERTO · 2020 to 2022
$747k
NIAAA NIH HHS AA006420NIAAA NIH HHS AA007456NIAAA NIH HHS AA013498NIAAA NIH HHS AA015566NIAAA NIH HHS AA017447NIAAA NIH HHS AA021491NIAAA NIH HHS AA025393NIAAA NIH HHS AA025996NIAAA NIH HHS AA027700NIAAA NIH HHS R00 AA025393NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R01 AA027700NIAAA NIH HHS R01 AA028879NIAAA NIH HHS R37 AA017447NIAAA NIH HHS T32 AA007456NIAAA NIH HHS U01 AA013498NIDA NIH HHS R21 DA046865NIMH NIH HHS R21 MH124036
6 · The paper itself

Abstract

Marchigian Sardinian alcohol-preferring (msP) rats serve as a unique model of heightened alcohol preference and anxiety disorders. Their innate enhanced stress and poor stress-coping strategies are driven by a genetic polymorphism of the corticotropin-releasing factor receptor 1 (

Indexed as

Behavior, AnimalAnimalsAnxietyArousalFemaleMaleMifepristoneRatsRats, WistarReceptors, GlucocorticoidSleep Wake DisordersMifepristoneReceptors, Glucocorticoidalcohol-preferring ratsanxietyglucocorticoid receptor antagonisthyperarousalmifepristonesleep disturbancesstress

Identifiers

PMID33803557
PMCPMC8003048
OpenAlexW3137841496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.