ArticleMaterials (Basel, Switzerland)2021
Carbon Dot/Naphthalimide Based Ratiometric Fluorescence Biosensor for Hyaluronidase Detection.
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 35 citations in OpenAlex.
- Enhanced biosensing of diabetes biomarkers by using rationally engineered carbon dots.RSC advances · 2026Review
- Enzyme cascade-induced optical sensing of hyaluronidase using an ultraviolet-modified liquid crystal interface.Mikrochimica acta · 2025Article
- Diagnosis of early-stage bladder cancer via unprocessed urine samples at the point of care.Nature biomedical engineering · 2025Article
- Chemical- and green-precursor-derived carbon dots for photocatalytic degradation of dyes.iScience · 2024Review
- Natural Nitrogen-Doped Carbon Dots Obtained from Hydrothermal Carbonization of Chebulic Myrobalan and Their Sensing Ability toward Heavy Metal Ions.Sensors (Basel, Switzerland) · 2023Article
- Recent Progress in Nanomaterial-Based Biosensors and Theranostic Nanomedicine for Bladder Cancer.Biosensors · 2023Review
- A Novel Dual-Emission Fluorescence Probe Based on CDs and EuMaterials (Basel, Switzerland) · 2022Article
- Carbon Dots Conjugated Antibody as an Effective FRET-Based Biosensor for Progesterone Hormone Screening.Biosensors · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bladder cancer is the leading cause of death in patients with genitourinary cancer. An elevated level of hyaluronidase (HAase) was found in bladder cancer, which acts as an important biomarker for the early diagnosis of bladder cancer. Hence, there is a need to develop a simple enzymatic assay for the early recognition of HAase. Herein, we report a simple, sensitive, and ratiometric fluorescence assay for HAase detection under physiological conditions. The fluorescence assay was constructed by the adsorption of cationic carbon dots and positively charged naphthalimide on negatively charged hyaluronic acid and the development of a Förster resonance energy transfer (FRET) mechanism from carbon dots to a naphthalimide fluorophores. The hyaluronidase enzyme cleaves the hyaluronic acid in this assay, and breaking down the FRET mechanism induces ratiometric changes. A detection limit of 0.09 U/mL was achieved, which is less than the HAase level found in normal human body fluids. Moreover, this assay may be used for diagnosing HAase-related diseases.
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