Evidence map›Paper›PMID 33803350›Full record

ReviewMetabolites2021

Automatic 1D

Roy Chih Chung Wang, David A Campbell, James R Green, Miroslava Čuperlović-Culf

Abstract readReview
In one paragraph

Review in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roy Chih Chung WangSchool of Mathematics and Statistics, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0002-1391-4536
David A CampbellSchool of Mathematics and Statistics, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0001-8722-4450
James R GreenDepartment of Systems and Computer Engineering, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0002-6039-2355
Miroslava Čuperlović-CulfDigital Technologies Research Center, National Research Council, Ottawa, ON K1A 0R6, Canada.ORCID 0000-0002-9483-8159

Funding

National Research Council Canada AI4D
6 · The paper itself

Abstract

High-throughput metabolomics can be used to optimize cell growth for enhanced production or for monitoring cell health in bioreactors. It has applications in cell and gene therapies, vaccines, biologics, and bioprocessing. NMR metabolomics is a method that allows for fast and reliable experimentation, requires only minimal sample preparation, and can be set up to take online measurements of cell media for bioreactor monitoring. This type of application requires a fully automated metabolite quantification method that can be linked with high-throughput measurements. In this review, we discuss the quantifier requirements in this type of application, the existing methods for NMR metabolomics quantification, and the performance of three existing quantifiers in the context of NMR metabolomics for bioreactor monitoring.

Indexed as

biomanufacturingbioprocessingbioreactorsmetabolite quantificationmetabolomicsNMRquantitative NMR

Identifiers

PMID33803350
PMCPMC8001003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.