Evidence map›Paper›PMID 33803199›Full record

ArticleMedicina (Kaunas, Lithuania)2021

Overlapping Genetic Background of Coronary Artery and Carotid/Femoral Atherosclerotic Calcification.

Anita Hernyes, Marton Piroska, Bence Fejer, Laszlo Szalontai, Helga Szabo, Bianka Forgo, Adam L Jermendy, Andrea A Molnar, Pal Maurovich-Horvat, Gyorgy Jermendy and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Anita HernyesMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1083 Budapest, Hungary.ORCID 0000-0001-5875-4006
Marton PiroskaMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1083 Budapest, Hungary.ORCID 0000-0002-6000-5044
Bence FejerMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1083 Budapest, Hungary.
Laszlo SzalontaiMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1083 Budapest, Hungary.
Helga SzaboMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1083 Budapest, Hungary.
Bianka ForgoDepartment of Radiology, Faculty of Medicine and Health, Örebro University, Södra Grev Rosengatan, 70185 Örebro, Sweden.ORCID 0000-0003-0627-1795
Adam L JermendyHeart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group, Semmelweis University, 18 Határőr Street, 1122 Budapest, Hungary.
Andrea A MolnarHeart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group, Semmelweis University, 18 Határőr Street, 1122 Budapest, Hungary.
Pal Maurovich-HorvatMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1083 Budapest, Hungary.
Gyorgy Jermendy3rd Department of Internal Medicine, Bajcsy Zsilinszky Hospital and Clinic, 89-91 Maglódi Street, 1106 Budapest, Hungary.ORCID 0000-0001-5596-7831
Bela MerkelyHeart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group, Semmelweis University, 18 Határőr Street, 1122 Budapest, Hungary.
David L TarnokiMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1083 Budapest, Hungary.ORCID 0000-0002-7001-7647
Adam D TarnokiMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1083 Budapest, Hungary.ORCID 0000-0001-5909-3780
Semmelweis University · HUBajcsy-Zsilinszky Kórház és Rendelőintézet · HUÖrebro University · SE

Funding

EFSD New Horizons Programme letter of advice date: 12.04.2013
6 · The paper itself

Abstract

BACKGROUND AND

objectivesMultivessel atherosclerosis and its genetic background are under-investigated, although atherosclerosis is seldom local and still causes high mortality. Alternative methods to assess coronary calcification (CAC) might incorporate genetic links between different arteries' atherosclerotic involvement, however, co-occurrences of coronary calcification have not been investigated in twins yet. MATERIALS AND

methodsWe assessed the heritability of radio morphologically distinct atherosclerotic plaque types in coronary (non-enhanced CT, Agatston score), carotid, and femoral arteries (B-mode ultrasound) in 190 twin subjects (60 monozygotic, 35 dizygotic pairs). Four-segment scores were derived in order to assess the dissemination of the distinct plaque types in the carotid and femoral arteries taking bilaterality into account. We calculated the genetic correlation between phenotypically correlating plaque types in these arteries.

resultsCAC and dissemination of calcified plaques in the carotid and femoral arteries (4S_hyper) were moderately heritable (0.67 [95% CI: 0.37-1] and 0.69 [95% CI: 0.38-1], respectively) when adjusted for age and sex. Hypoechoic plaques in the carotid and femoral arteries showed no heritability, while mixed plaques showed intermediate heritability (0.50 [95% CI: 0-0.76]). Age and sex-adjusted phenotypic correlation between CAC and 4segm_hyper was 0.48 [95% CI: 0.30-0.63] and the underlying genetic correlation was 0.86 [95% CI: 0.42-1].

conclusionsCalcification of atherosclerotic plaques is moderately heritable in all investigated arteries and significant overlapping genetic factors can be attributed to the phenotypical resemblance of coronary and carotid or femoral atherosclerotic calcification. Our findings support the idea of screening extracoronary arteries in asymptomatic individuals. We also propose a hypothesis about primarily carotid-coronary and femoral-coronary atherosclerosis as two distinct genetic predispositions to co-localization.

Indexed as

AtherosclerosisCarotid Artery DiseasesCoronary Artery DiseaseCoronary VesselsFemoral ArteryGenetic BackgroundHumansRisk Factorsatherosclerosiscoronary artery calcificationgenetic correlationheritabilitymultivesselplaque calcificationtwin study

Identifiers

PMID33803199
PMCPMC7999274
OpenAlexW3134056575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.