Evidence map›Paper›PMID 33803115›Full record

ArticleJournal of clinical medicine2021

MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation.

Luis M Blanco-Colio, Nerea Méndez-Barbero, Ana María Pello Lázaro, Álvaro Aceña, Nieves Tarín, Carmen Cristóbal, Juan Martínez-Milla, Óscar González-Lorenzo, José Luis Martín-Ventura, Ana Huelmos and 9 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
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  5. Beyond CYP2C19: inflammation and angiogenesis gene variants drive clopidogrel resistance in CAD patients.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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  15. Technological Advances in the Diagnosis of Cardiovascular Disease: A Public Health Strategy.International journal of environmental research and public health · 2024
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Luis M Blanco-ColioVascular Research Lab, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.ORCID 0000-0002-1560-6609
Nerea Méndez-BarberoVascular Research Lab, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Ana María Pello LázaroDepartment of Cardiology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Álvaro AceñaDepartment of Cardiology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.ORCID 0000-0002-5975-5761
Nieves TarínDepartment of Cardiology, Hospital Universitario de Móstoles, 28935 Madrid, Spain.
Carmen CristóbalDepartment of Cardiology, Hospital de Fuenlabrada, 28942 Madrid, Spain.
Juan Martínez-MillaDepartment of Cardiology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Óscar González-LorenzoDepartment of Cardiology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
José Luis Martín-VenturaVascular Research Lab, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Ana HuelmosDepartment of Cardiology, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain.
Carlos Gutiérrez-LandaluceDepartment of Cardiology, Hospital de Fuenlabrada, 28942 Madrid, Spain.ORCID 0000-0001-5807-0894
Marta López-CastilloDepartment of Cardiology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Andrea KallmeyerDepartment of Cardiology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Ester CánovasDepartment of Cardiology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Joaquín AlonsoDepartment of Cardiology, Hospital de Getafe, 28905 Madrid, Spain.
Lorenzo López BescósDepartment of Cardiology, Rey Juan Carlos University, Alcorcón, 28933 Madrid, Spain.
Jesús EgidoDepartment of Medicine, Autónoma University, 08193 Madrid, Spain.
Óscar LorenzoDepartment of Medicine, Autónoma University, 08193 Madrid, Spain.ORCID 0000-0001-5515-6078
José TuñónVascular Research Lab, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.ORCID 0000-0002-1373-0999
Hospital Universitario Fundación Jiménez Díaz · ESInstituto de Salud Carlos III · ESUniversidad Rey Juan Carlos · ESHospital Universitario de Fuenlabrada · ESHospital Universitario de Getafe · ESHospital Universitario de Móstoles · ESHospital Universitario Fundación Alcorcón · ES

Funding

Instituto de Salud Carlos III PI14/1567, PI05/0451, PI16/01419, PI17/01615, PI17/01495, PI19/00128Ministerio de Ciencia e Innovación RTC2019-006826-1
6 · The paper itself

Abstract

Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated with high risk of cardiovascular disease (CVD). We determined whether a panel of biomarkers associated with CVD could predict recurrent events in patients with low or persistent inflammation and coronary artery disease (CAD). We followed 917 patients with CAD (median 4.59 ± 2.39 years), assessing CRP, galectin-3, monocyte chemoattractant protein-1 (MCP-1), N-terminal fragment of brain natriuretic peptide (NT-proBNP) and troponin-I plasma levels. The primary outcome was the combination of cardiovascular events (acute coronary syndrome, stroke or transient ischemic event, heart failure or death). Patients with persistent inflammation (

Indexed as

C-reactive proteininflammationMCP-1NT-proBNP

Identifiers

PMID33803115
PMCPMC7963189
OpenAlexW3134982286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.