Evidence map›Paper›PMID 33803075›Full record

ArticleInternational journal of molecular sciences2021

Methamphetamine Blocks Adenosine A

Mireia Casanovas, Irene Reyes-Resina, Alejandro Lillo, Jaume Lillo, Raul López-Arnau, Jorge Camarasa, Elena Escubedo, Gemma Navarro, Rafael Franco

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mireia CasanovasBiology School, Department of Biochemistry and Molecular Biomedicine, University of Barcelona, 08028 Barcelona, Spain.
Irene Reyes-ResinaBiology School, Department of Biochemistry and Molecular Biomedicine, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0003-2077-2537
Alejandro LilloDepartment of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
Jaume LilloBiology School, Department of Biochemistry and Molecular Biomedicine, University of Barcelona, 08028 Barcelona, Spain.
Raul López-ArnauDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0001-8904-7398
Jorge CamarasaDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain.
Elena EscubedoDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-5078-366X
Gemma NavarroCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), Instituto de Salud Carlos III, 28031 Madrid, Spain.ORCID 0000-0003-4654-0873
Rafael FrancoCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), Instituto de Salud Carlos III, 28031 Madrid, Spain.ORCID 0000-0003-2549-4919
Universitat de Barcelona · ESInstituto de Salud Carlos III · ES

Funding

Ministerio de Economía, Industria y Competitividad, Gobierno de España SAF2017-84117-R 627; RTI2018-09204-B-I00US Alzheimer Association AARFD-17-503612
6 · The paper itself

Abstract

Methamphetamine is, worldwide, one of the most consumed drugs of abuse. One important side effect is neurodegeneration leading to a decrease in life expectancy. The aim of this paper was to check whether the drug affects one of the receptors involved in neurodegeneration/neuroprotection events, namely the adenosine A

Indexed as

Adenosine A2 Receptor AntagonistsAnimalsCorpus StriatumExtracellular Signal-Regulated MAP KinasesHEK293 CellsHumansMAP Kinase Signaling SystemMethamphetamineMiceNeuronsReceptor, Adenosine A2AReceptor, Cannabinoid, CB1Receptors, sigmaSigma-1 ReceptorAdenosine A2 Receptor AntagonistsADORA2A protein, humanAdora2a protein, mouseCNR1 protein, mouseExtracellular Signal-Regulated MAP KinasesMethamphetamineReceptor, Adenosine A2AReceptor, Cannabinoid, CB1Receptors, sigmaSigma-1 Receptordrug of abuseG protein-coupled receptor GPCRheteromerneuroprotectionstriatal neurons

Identifiers

PMID33803075
PMCPMC7963146
OpenAlexW3134199784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.