Evidence map›Paper›PMID 33802936›Full record

ReviewInternational journal of molecular sciences2021

miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies.

Duy N Do, Pier-Luc Dudemaine, Manisha Mathur, Prashanth Suravajhala, Xin Zhao, Eveline M Ibeagha-Awemu

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. MiRNAs in Poultry Health and Production: Progress and Challenges.Animals : an open access journal from MDPI · 2025
    Review
  9. Article
  10. Article
  11. Regulation of energy metabolism by non-coding RNAs in livestock species: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Duy N DoAgriculture and Agri-Food Canada, Sherbrooke Research and Development Centre, Sherbrooke, QC J1M 0C8, Canada.ORCID 0000-0002-7527-9320
Pier-Luc DudemaineAgriculture and Agri-Food Canada, Sherbrooke Research and Development Centre, Sherbrooke, QC J1M 0C8, Canada.
Manisha MathurAdvanced Milk Testing Research Laboratory, Postgraduate Institute of Veterinary Education and Research, Institute of Veterinary Education and Research (RAJUVAS), Jaipur 302001, Rajasthan, India.ORCID 0000-0002-6142-6318
Prashanth SuravajhalaDepartment of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, Rajasthan, India.ORCID 0000-0002-8535-278X
Xin ZhaoDepartment of Animal Science, McGill University, Ste-Anne-de Bellevue, QC H9X 3V9, Canada.
Eveline M Ibeagha-AwemuAgriculture and Agri-Food Canada, Sherbrooke Research and Development Centre, Sherbrooke, QC J1M 0C8, Canada.ORCID 0000-0001-8810-9294

Funding

Agriculture and Agri-Food Canada J-002223
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene expression post-transcriptionally by targeting either the 3' untranslated or coding regions of genes. They have been reported to play key roles in a wide range of biological processes. The recent remarkable developments of transcriptomics technologies, especially next-generation sequencing technologies and advanced bioinformatics tools, allow more in-depth exploration of messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs), including miRNAs. These technologies have offered great opportunities for a deeper exploration of miRNA involvement in farm animal diseases, as well as livestock productivity and welfare. In this review, we provide an overview of the current knowledge of miRNA roles in major farm animal diseases with a particular focus on diseases of economic importance. In addition, we discuss the steps and future perspectives of using miRNAs as biomarkers and molecular therapy for livestock disease management as well as the challenges and opportunities for understanding the regulatory mechanisms of miRNAs related to disease pathogenesis.

Indexed as

Gene Expression RegulationAnimal DiseasesAnimalsAnimals, DomesticBiomarkersHumansLivestockMicroRNAsBiomarkersMicroRNAsbiomarkersfoot-and-mouth diseaselivestock diseasesMarek’s diseasemastitismiRNAsPRRSVregulatory networksRNAi therapy

Identifiers

PMID33802936
PMCPMC8002598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.