Evidence map›Paper›PMID 33802897›Full record

ArticleEntropy (Basel, Switzerland)2021

Experimental and Theoretical Analysis of Metal Complex Diffusion through Cell Monolayer.

Katarzyna Gałczyńska, Jarosław Rachuna, Karol Ciepluch, Magdalena Kowalska, Sławomir Wąsik, Tadeusz Kosztołowicz, Katarzyna D Lewandowska, Jacek Semaniak, Krystyna Kurdziel, Michał Arabski

Open access · goldAbstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katarzyna GałczyńskaInstitute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Jarosław RachunaInstitute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Karol CiepluchInstitute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Magdalena KowalskaInstitute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Sławomir WąsikInstitute of Physics, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.ORCID 0000-0003-0107-4493
Tadeusz KosztołowiczInstitute of Physics, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.ORCID 0000-0001-5710-2970
Katarzyna D LewandowskaDepartment of Radiological Informatics and Statistics, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland.
Jacek SemaniakInstitute of Physics, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Krystyna KurdzielInstitute of Chemistry, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Michał ArabskiInstitute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.ORCID 0000-0002-9712-9286
Jan Kochanowski University · PLGdańsk Medical University · PL

Funding

Ministry of Science and Higher Education, Poland SMGR.RN.20.096Ministry of Science and Higher Education, Poland SMGR.RN.20.222.628
6 · The paper itself

Abstract

The study of drugs diffusion through different biological membranes constitutes an essential step in the development of new pharmaceuticals. In this study, the method based on the monolayer cell culture of CHO-K1 cells has been developed in order to emulate the epithelial cells barrier in permeability studies by laser interferometry. Laser interferometry was employed for the experimental analysis of nickel(II) and cobalt(II) complexes with 1-allylimidazole or their chlorides' diffusion through eukaryotic cell monolayers. The amount (mol) of nickel(II) and cobalt(II) chlorides transported through the monolayer was greater than that of metals complexed with 1-allylimidazole by 4.34-fold and 1.45-fold, respectively, after 60 min. Thus, laser interferometry can be used for the quantitative analysis of the transport of compounds through eukaryotic cell monolayers, and the resulting parameters can be used to formulate a mathematical description of this process.

Indexed as

1-allylimidazole complexcobalt(II)diffusioneukaryotic cell monolayerimidazolelaser interferometrymetal complexnickel(II)

Identifiers

PMID33802897
PMCPMC8002612
OpenAlexW3137698331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.