Evidence map›Paper›PMID 33802862›Full record

ArticleGenes2021

Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era.

Steven R Bentley, Ilaria Guella, Holly E Sherman, Hannah M Neuendorf, Alex M Sykes, Javed Y Fowdar, Peter A Silburn, Stephen A Wood, Matthew J Farrer, George D Mellick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Steven R BentleyGriffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD 4111, Australia.ORCID 0000-0002-1888-8488
Ilaria GuellaDjavad Mowafhagian Centre for Brain, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Holly E ShermanDjavad Mowafhagian Centre for Brain, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Hannah M NeuendorfGriffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD 4111, Australia.ORCID 0000-0001-5238-5529
Alex M SykesGriffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD 4111, Australia.ORCID 0000-0001-8981-6652
Javed Y FowdarGriffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD 4111, Australia.
Peter A SilburnCentre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia.
Stephen A WoodGriffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD 4111, Australia.
Matthew J FarrerDjavad Mowafhagian Centre for Brain, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
George D MellickGriffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, QLD 4111, Australia.
Griffith University · AUUniversity of British Columbia · CAThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is typically sporadic; however, multi-incident families provide a powerful platform to discover novel genetic forms of disease. Their identification supports deciphering molecular processes leading to disease and may inform of new therapeutic targets. The

Indexed as

Mutation, MissenseExome SequencingFemaleGenetic Predisposition to DiseaseGTPase-Activating ProteinsHeterozygoteHigh-Throughput Nucleotide SequencingHumansMaleParkinson DiseasePedigreePotassium Channels, Inwardly RectifyingGTPase-Activating ProteinsKCNJ15 protein, humanPotassium Channels, Inwardly RectifyingSIPA1L1 protein, humanexomefamilialmovement disordermulti-incidentmutationparkinsonism

Identifiers

PMID33802862
PMCPMC8002626
OpenAlexW3138070313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.