Evidence map›Paper›PMID 33802857›Full record

ReviewViruses2021

SARS-CoV-2 Infections in Animals: Reservoirs for Reverse Zoonosis and Models for Study.

Tessa Prince, Shirley L Smith, Alan D Radford, Tom Solomon, Grant L Hughes, Edward I Patterson

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 106 citations in OpenAlex.

  1. Spike destabilization attenuates Mink Cluster 5 SARS-CoV-2.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  4. Article
  5. Review
  6. Article
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  9. Assessing the Potential Role of Cats (Pathogens (Basel, Switzerland) · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The future of hepatology.Hepatology (Baltimore, Md.) · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Tessa PrinceNIHR Health Protection Unit in Emerging and Zoonotic Infections, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool L69 7TX, UK.
Shirley L SmithInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.
Alan D RadfordInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.
Tom SolomonNIHR Health Protection Unit in Emerging and Zoonotic Infections, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool L69 7TX, UK.
Grant L HughesNIHR Health Protection Unit in Emerging and Zoonotic Infections, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool L69 7TX, UK.ORCID 0000-0002-7567-7185
Edward I PattersonCentre for Neglected Tropical Disease, Departments of Vector Biology and Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.ORCID 0000-0003-3465-0848
University of Liverpool · GBBrock University · CA

Funding

Microbial interplay between ZIKA virus and the native microbiome in mosquitoesR21AI129507 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HUGHES, GRANT LESLIE · 2017 to 2018
$371k
Exploiting gnotobiotic systems to examine microbiota acquisition in mosquitoes and for microbiome transplantationsR21AI138074 · NIAID · TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE · PI HUGHES, GRANT LESLIE · 2018 to 2019
$296k
NIAID NIH HHS R21 AI129507NIAID NIH HHS R21 AI138074
6 · The paper itself

Abstract

The recent SARS-CoV-2 pandemic has brought many questions over the origin of the virus, the threat it poses to animals both in the wild and captivity, and the risks of a permanent viral reservoir developing in animals. Animal experiments have shown that a variety of animals can become infected with the virus. While coronaviruses have been known to infect animals for decades, the true intermediate host of the virus has not been identified, with no cases of SARS-CoV-2 in wild animals. The screening of wild, farmed, and domesticated animals is necessary to help us understand the virus and its origins and prevent future outbreaks of both COVID-19 and other diseases. There is intriguing evidence that farmed mink infections (acquired from humans) have led to infection of other farm workers in turn, with a recent outbreak of a mink variant in humans in Denmark. A thorough examination of the current knowledge and evidence of the ability of SARS-CoV-2 to infect different animal species is therefore vital to evaluate the threat of animal to human transmission and reverse zoonosis.

Indexed as

AnimalsAnimals, WildCOVID-19Disease ReservoirsHumansSARS-CoV-2ZoonosesanimalsCOVID-19intermediate hostreverse zoonosisSARS-CoV-2

Identifiers

PMID33802857
PMCPMC8002747
OpenAlexW3135956255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.