Evidence map›Paper›PMID 33802843›Full record

ArticleInternational journal of molecular sciences2021

Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl.

Dietrich E Lorke, Syed M Nurulain, Mohamed Y Hasan, Kamil Kuča, Georg A Petroianu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Dietrich E LorkeDepartment of Anatomy and Cellular Biology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates.ORCID 0000-0003-1821-8801
Syed M NurulainBio Science Department, COMSATS Institute of Information Technology, Bio Sciences Block, CUI, Park Road, Tarlai Kalan, Islamabad 45550, Pakistan.ORCID 0000-0001-6146-1511
Mohamed Y HasanDepartment of Pharmacology & Therapeutics, College of Medicine and Health Sciences, UAE University, Al Ain P.O. Box 15551, United Arab Emirates.
Kamil KučaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanského 62/26, 500 03 Hradec Kralove, Czech Republic.ORCID 0000-0001-9664-1109
Georg A PetroianuDepartment of Pharmacology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates.
Khalifa University of Science and Technology · AECOMSATS University Islamabad · PKUnited Arab Emirates University · AEUniversity of Hradec Králové · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poisoning with organophosphorus compounds (OPCs) represents an ongoing threat to civilians and rescue personal. We have previously shown that oximes, when administered prophylactically before exposure to the OPC paraoxon, are able to protect from its toxic effects. In the present study, we have assessed to what degree experimental (K-27; K-48; K-53; K-74; K-75) or established oximes (pralidoxime, obidoxime), when given as pretreatment at an equitoxic dosage of 25% of LD

Indexed as

AnimalsAzinphosmethylCholinesterase InhibitorsInhibitory Concentration 50Molecular WeightOrganophosphorus CompoundsOximesPesticidesProportional Hazards ModelsRatsRats, WistarRiskSurvival AnalysisAzinphosmethylCholinesterase InhibitorsOrganophosphorus CompoundsOximesPesticidesacetylcholineazinphos-methylcarbamatescholinesteraseCox analysisobidoximeorganophosphatepesticidepralidoximeprophylaxisrat

Identifiers

PMID33802843
PMCPMC8002820
OpenAlexW3138123947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.