Evidence map›Paper›PMID 33802822›Full record

ArticleInternational journal of molecular sciences2021

Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome.

Evagelia C Laiakis, Igor Shuryak, Annabella Deziel, Yi-Wen Wang, Brooke L Barnette, Yongjia Yu, Robert L Ullrich, Albert J Fornace, Mark R Emmett

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Evagelia C LaiakisLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.ORCID 0000-0002-4924-9013
Igor ShuryakCenter for Radiological Research, Columbia University, New York, NY 10032, USA.
Annabella DezielLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.
Yi-Wen WangLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.
Brooke L BarnetteDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-7044-0787
Yongjia YuDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Robert L UllrichRadiation Effects Research Foundation, Hiroshima 732-0815, Japan.
Albert J FornaceLombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.ORCID 0000-0001-9695-085X
Mark R EmmettDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Georgetown University · USThe University of Texas Medical Branch at Galveston · USColumbia University · USRadiation Effects Research Foundation · JP

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
NASA NNX15AD65GNCI NIH HHS P30 CA051008U.S. Department of Energy DEHS0000031
6 · The paper itself

Abstract

Future space missions will include a return to the Moon and long duration deep space roundtrip missions to Mars. Leaving the protection that Low Earth Orbit provides will unavoidably expose astronauts to higher cumulative doses of space radiation, in addition to other stressors, e.g., microgravity. Immune regulation is known to be impacted by both radiation and spaceflight and it remains to be seen whether prolonged effects that will be encountered in deep space can have an adverse impact on health. In this study, we investigated the effects in the overall metabolism of three different low dose radiation exposures (γ-rays,

Indexed as

Cosmic RadiationRadiation ExposureAnimalsCitric Acid CycleDose-Response Relationship, RadiationLinear ModelsMaleMetabolomeMiceMice, Inbred C57BLMultivariate AnalysisPurinesSpleenPurinesimmunemetabolismmitochondriaspace radiationspleen

Identifiers

PMID33802822
PMCPMC8002539
OpenAlexW3138475664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.