Evidence map›Paper›PMID 33802672›Full record

ArticleInternational journal of molecular sciences2021

Transcriptional Repression of Raf Kinase Inhibitory Protein Gene by Metadherin during Cancer Progression.

Trang Huyen Lai, Mahmoud Ahmed, Jin Seok Hwang, Sahib Zada, Trang Minh Pham, Omar Elashkar, Deok Ryong Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Regulation of TGF-Cancers · 2022
    Article
  3. Review
  4. Transcription Factors in Cancer.International journal of molecular sciences · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Trang Huyen LaiDepartment of Convergence Medical Science and Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 527-27, Korea.ORCID 0000-0003-4619-6558
Mahmoud AhmedDepartment of Convergence Medical Science and Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 527-27, Korea.ORCID 0000-0002-4377-6541
Jin Seok HwangDepartment of Convergence Medical Science and Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 527-27, Korea.ORCID 0000-0002-2051-504X
Sahib ZadaDepartment of Convergence Medical Science and Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 527-27, Korea.ORCID 0000-0002-7664-3323
Trang Minh PhamDepartment of Convergence Medical Science and Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 527-27, Korea.ORCID 0000-0003-1862-464X
Omar ElashkarDepartment of Convergence Medical Science and Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 527-27, Korea.ORCID 0000-0002-5505-778X
Deok Ryong KimDepartment of Convergence Medical Science and Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 527-27, Korea.ORCID 0000-0002-3288-8257
Gyeongsang National University · KR

Funding

Ministry of Science and ICT, South Korea 2015R1A5A2008833 and 2020R1A2C2011416
6 · The paper itself

Abstract

Raf kinase inhibitory protein (RKIP), also known as a phosphatidylethanolamine-binding protein 1 (PEBP1), functions as a tumor suppressor and regulates several signaling pathways, including ERK and NF-κκB. RKIP is severely downregulated in human malignant cancers, indicating a functional association with cancer metastasis and poor prognosis. The transcription regulation of

Indexed as

Disease ProgressionTranscription, GeneticCell Line, TumorDNA-Binding ProteinsGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMembrane ProteinsMutationNeoplasmsPhosphatidylethanolamine Binding ProteinPromoter Regions, GeneticProtein BindingRNA-Binding ProteinsTranscriptional ActivationTranscription FactorsDNA-Binding ProteinsMembrane ProteinsMTDH protein, humanPEBP1 protein, humanPhosphatidylethanolamine Binding ProteinRNA-Binding ProteinsTranscription FactorsVEZF1 protein, humanChIP assayMTDH/AEG-1promoter assayRKIP expressionRKIP/PEBP1transcription factorVEZF1

Identifiers

PMID33802672
PMCPMC8002422
OpenAlexW3136104066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.