ArticlePharmaceutics2021
Development and Characterization of Xanthan Gum and Alginate Based Bioadhesive Film for Pycnogenol Topical Use in Wound Treatment.
Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Olive Mill Wastewater-Loaded Polysaccharide Hydrogels as Potential Antibacterial Films for Wound Healing.Gels (Basel, Switzerland) · 2026Article
- Enhanced Barley Growth in Petroleum-Contaminated Soil Mediated by Xanthan-like Exopolysaccharide ofMicroorganisms · 2026Article
- Optimization of Film-Dressings Containing Herbal Extracts for Wound Care-A Quality by Design Approach.Gels (Basel, Switzerland) · 2025Article
- Chemically Crosslinked Alginate Hydrogel with Polyaziridine: Effects on Physicochemical Properties and Promising Applications.ChemPlusChem · 2025Article
- Article
- Nitrocellulose Based Film-Forming Gels with Cinnamon Essential Oil for Covering Surface Wounds.Polymers · 2023Article
- AntibacterialInternational journal of molecular sciences · 2023Article
- Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents.Pharmaceutics · 2023Review
- Biomaterial Inks from Peptide-Functionalized Silk Fibers for 3D Printing of Futuristic Wound-Healing and Sensing Materials.International journal of molecular sciences · 2023Article
- Characterisation of Films Based on Exopolysaccharides fromPolymers · 2022Article
- Design, Characterization, and Anticancer and Antimicrobial Activities of Mucoadhesive Oral Patches Loaded withAntioxidants (Basel, Switzerland) · 2022Article
- Evaluation ofAntioxidants (Basel, Switzerland) · 2022Article
- Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art.International journal of molecular sciences · 2022Review
- Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract.Pharmaceutics · 2022Article
- Article
- HWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pycnogenol (PYC) is a concentrate of phenolic compounds derived from French maritime pine; its biological activity as antioxidant, anti-inflammatory and antibacterial suggests its use in the treatment of open wounds. A bioadhesive film, loaded with PYC, was prepared by casting, starting with a combination of two biopolymer acqueous solutions: xanthan gum (1% wt/wt) and sodium alginate (1.5% wt/wt), in a 2.5/7.5 (wt/wt) ratio. In both solutions, glycerol (10% wt/wt) was added as plasticizing agent. The film resulted in an adhesive capable to absorb a simulated wound fluid (~ 65% wt/wt within 1 h), therefore suitable for exuding wounds. The mechanical characterization showed that the film is deformable (elastic modulus E = 3.070 ± 0.044 MPa), suggesting adaptability to any type of surface and resistance to mechanical solicitations. PYC is released within 24 h by a sustained mechanism, achieving a maximum concentration of ~ 0.2 mg/mL, that is safe for keratinocytes, as shown by cytotoxicity studies. A concentration of 0.015 mg/mL is reached in the first 5 min after application, at which point PYC stimulates keratinocyte growth. These preliminary results suggest the use of PYC in formulations designed for topical use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.