ReviewJournal of personalized medicine2021
Diet, Obesity, and Depression: A Systematic Review.
Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 5 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Burden and Risk of Depression in Patients Receiving Semaglutide: A Systematic Review and Meta-Analysis.Clinical obesity · 2026Pooled it
- Child and Adolescent Health Programs in Obesity and Depression: A Systematic Review and Meta-Analysis.Nutrients · 2025Pooled it
- The efficacy of topical aminophylline in local fat reduction: A systematic review.Frontiers in endocrinology · 2023Pooled it
- Effectiveness of low-carbohydrate diets for long-term weight loss in obese individuals: A meta-analysis of randomized controlled trials.Diabetes, obesity & metabolism · 2022Pooled it
- Associations between dietary intake, diet quality and depressive symptoms in youth: A systematic review of observational studies.Health promotion perspectives · 2022Pooled it
- Trial
- Effect of Time-Restricted Eating versus Daily Calorie Restriction on Mood and Quality of Life in Adults with Obesity.Nutrients · 2023Trial
- Traditional Dairy and Olive Food Preferences Are Associated with Mediterranean Diet Adherence in Cyprus.Foods (Basel, Switzerland) · 2026Article
- Evaluation of the relationship between sustainable and healthy eating behaviours, phytochemical index, anthropometric measurements, and depression in young adults.Scientific reports · 2026Article
- Lower Daily Walking Volume and Less Walking at Intermediate and Higher Cadences in Older Women with Clinician-Diagnosed Major Depressive Disorder: An Exploratory Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Weight Management Post-Stroke: A Scoping Review.American journal of lifestyle medicine · 2026Review
- Psychometric Validation of the Weight and Emotions Scale (WES) in Adults with Obesity or Overweight.Advances in therapy · 2026Article
- Article
- Article
- Metabolic dysfunction and insulin resistance in depression: mechanisms, evidence, and therapeutic implications.Frontiers in psychiatry · 2026Review
- Impact of Obesity, Menopause, and Depression in Women's Health: An Attempt to Decipher the Complex Relationship.Current medicinal chemistry · 2026Review
- Abdominal Obesity Indices as Predictors of Psychiatric Morbidity in a Large-Scale Taiwanese Cohort.Nutrients · 2025Article
- Exploring the role of obesity in predicting mental health disorders: analyzing the effects of diagnosis sequence order.BMC psychiatry · 2025Article
- Effectiveness of improving nutrition on depressive symptoms and work ability: Study protocol for the mind nutrition randomized controlled trial.Nutrition and health · 2025Article
- Consumption of High-Energy Food and Sugar Shows a Strong Positive Association with Low Mood in Control Subjects and Depressed Patients.Nutrients · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity and depression co-occur in a significant proportion of the population. Mechanisms linking the two disorders include the immune and the endocrine system, psychological and social mechanisms. The aim of this systematic review was to ascertain whether weight loss through dietary interventions has the additional effect of ameliorating depressive symptoms in obese patients.
methodsWe systematically searched three databases (Pubmed, Medline, Embase) for longitudinal clinical trials testing a dietary intervention in people with obesity and depression or symptoms of depression.
resultsTwenty-four longitudinal clinical studies met the eligibility criteria with a total of 3244 included patients. Seventeen studies examined the effects of calorie-restricted diets and eight studies examined dietary supplements (two studies examined both). Only three studies examined people with a diagnosis of both obesity and depression. The majority of studies showed that interventions using a calorie-restricted diet resulted in decreases in depression scores, with effect sizes between ≈0.2 and ≈0.6. The results were less clear for dietary supplements.
conclusionsPeople with obesity and depression appear to be a specific subgroup of depressed patients in which calorie-restricted diets might constitute a promising personalized treatment approach. The reduction of depressive symptoms may be related to immunoendocrine and psychosocial mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.