Evidence map›Paper›PMID 33802476›Full record

ArticleBiomedicines2021

In Silico Drug Repurposing by Structural Alteration after Induced Fit: Discovery of a Candidate Agent for Recovery of Nucleotide Excision Repair in Xeroderma Pigmentosum Group D Mutant (R683W).

Yutaka Takaoka, Mika Ohta, Satoshi Tateishi, Aki Sugano, Eiji Nakano, Kenji Miura, Takashi Suzuki, Chikako Nishigori

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yutaka TakaokaDivision of Medical Informatics and Bioinformatics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0001-7568-8135
Mika OhtaDivision of Medical Informatics and Bioinformatics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Satoshi TateishiInstitute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.
Aki SuganoDivision of Medical Informatics and Bioinformatics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Eiji NakanoDivision of Dermatology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.ORCID 0000-0001-7632-8182
Kenji MiuraDivision of Medical Informatics and Bioinformatics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Takashi SuzukiDivision of Medical Informatics and Bioinformatics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Chikako NishigoriDivision of Dermatology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Kobe University · JPKobe Tokiwa University · JPKumamoto University · JP

Funding

Japan Agency for Medical Research and Development 16ek0109028h0003Japanese Ministry of Health and Welfare 36Japan Society for the Promotion of Science 18K07414Japan Society for the Promotion of Science 19K012202
6 · The paper itself

Abstract

Xeroderma pigmentosum complementation group D (XPD) is a UV-sensitive syndrome and a rare incurable genetic disease which is caused by the genetic mutation of the excision repair cross-complementation group 2 gene (

Indexed as

4E1RCatATP bindingdrug repurposinginduced fitmolecular dynamics simulationnucleotide excision repairxeroderma pigmentosum complementation group D

Identifiers

PMID33802476
PMCPMC7999925
OpenAlexW3135700395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.