Evidence map›Paper›PMID 33802460›Full record

ArticleInternational journal of molecular sciences2021

GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice.

Martijn J C van der Lienden, Jan Aten, André R A Marques, Ingeborg S E Waas, Per W B Larsen, Nike Claessen, Nicole N van der Wel, Roelof Ottenhoff, Marco van Eijk, Johannes M F G Aerts

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Martijn J C van der LiendenDepartment Medical Biochemistry, Leiden University, 2333 CC Leiden, The Netherlands.ORCID 0000-0002-6458-1479
Jan AtenDepartment of Pathology, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.ORCID 0000-0002-0997-6777
André R A MarquesChronic Diseases Research Centre, Universidade NOVA de Lisboa, 1150-082 Lisbon, Portugal.ORCID 0000-0001-9674-3017
Ingeborg S E WaasDepartment of Pathology, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Per W B LarsenDepartment of Pathology, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Nike ClaessenDepartment of Pathology, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Nicole N van der WelElectron Microscopy Center Amsterdam, Department of Medical Biology, Amsterdam UMC, 1100 DD Amsterdam, The Netherlands.ORCID 0000-0001-6392-3417
Roelof OttenhoffDepartment of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
Marco van EijkDepartment Medical Biochemistry, Leiden University, 2333 CC Leiden, The Netherlands.
Johannes M F G AertsDepartment Medical Biochemistry, Leiden University, 2333 CC Leiden, The Netherlands.ORCID 0000-0001-8168-2565
Amsterdam University Medical Centers · NLLeiden University · NLUniversidade Nova de Lisboa · PT

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek BBOL-2007247202
6 · The paper itself

Abstract

The lysosomal storage disease Niemann-Pick type C (NPC) is caused by impaired cholesterol efflux from lysosomes, which is accompanied by secondary lysosomal accumulation of sphingomyelin and glucosylceramide (GlcCer). Similar to Gaucher disease (GD), patients deficient in glucocerebrosidase (GCase) degrading GlcCer, NPC patients show an elevated glucosylsphingosine and glucosylated cholesterol. In livers of mice lacking the lysosomal cholesterol efflux transporter NPC1, we investigated the expression of established biomarkers of lipid-laden macrophages of GD patients, their GCase status, and content on the cytosol facing glucosylceramidase GBA2 and lysosomal integral membrane protein type B (LIMP2), a transporter of newly formed GCase to lysosomes. Livers of 80-week-old

Indexed as

AnimalsBiological TransportCathepsin DCell LineCell Line, TumorGaucher DiseaseGlucosylceramidaseGlucosylceramidesHepatocytesHep G2 CellsHumansLiverLysosomal Membrane ProteinsLysosomesMacrophagesMiceCathepsin DGlucosylceramidaseGlucosylceramidesLysosomal Membrane ProteinsReceptors, ScavengerSCARB2 protein, humanSphingomyelinsGCaseGPNMBLIMP2lysosomemacrophageNPCNPC1storage

Identifiers

PMID33802460
PMCPMC7959463
OpenAlexW3134294420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.