Evidence map›Paper›PMID 33802371›Full record

ReviewMicroorganisms2021

Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods.

Eugenia Bezirtzoglou, Elisavet Stavropoulou, Konstantina Kantartzi, Christina Tsigalou, Chrysa Voidarou, Gregoria Mitropoulou, Ioanna Prapa, Valentini Santarmaki, Vasiliki Kompoura, Amalia E Yanni and 3 more

Abstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Assessment of ImmobilizedFoods (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Review
  7. Effect of date seed (BMJ open · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eugenia BezirtzoglouLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, Greece.ORCID 0000-0002-2010-2544
Elisavet StavropoulouCentre Hospitalier Universitaire Vaudois (CHUV), rue du Bugnon, 1011 Lausanne, Switzerland.
Konstantina KantartziDepartment of Medicine, Nephrology Clinic, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, Greece.
Christina TsigalouLaboratory of Microbiology, Department of Medicine, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, Greece.ORCID 0000-0002-7869-6824
Chrysa VoidarouDepartment of Public Health P.U., Prefecture of Epirus, 47132 Arta, Greece.
Gregoria MitropoulouLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, Greece.
Ioanna PrapaLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, Greece.ORCID 0000-0003-0280-4443
Valentini SantarmakiLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, Greece.
Vasiliki KompouraLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, Greece.ORCID 0000-0003-0880-0275
Amalia E YanniLaboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics, Harokopion University, 17671 Athens, Greece.
Maria AntoniadouDental School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0001-7333-3066
Theodoros VarzakasDepartment of Food Science and Technology, University of the Peloponnese, 24100 Kalamata, Greece.ORCID 0000-0003-3927-9056
Yiannis KourkoutasLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, Greece.ORCID 0000-0003-2842-7666

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last decades, the incidence of diabetes has increased in developed countries and beyond the genetic impact, environmental factors, which can trigger the activation of the gut immune system, seem to affect the induction of the disease process. Since the composition of the gut microbiome might disturb the normal interaction with the immune system and contribute to altered immune responses, the restoration of normal microbiota composition constitutes a new target for the prevention and treatment of diabetes. Thus, the interaction of gut microbiome and diabetes, focusing on mechanisms connecting gut microbiota with the occurrence of the disorder, is discussed in the present review. Finally, the challenge of functional food diet on maintaining intestinal health and microbial flora diversity and functionality, as a potential tool for the onset inhibition and management of the disease, is highlighted by reporting key animal studies and clinical trials. Early onset of the disease in the oral cavity is an important factor for the incorporation of a functional food diet in daily routine.

Indexed as

diabetesdigestive healthfermented foodsfunctional foodsgut microbiomenutritionprebioticsprobiotics

Identifiers

PMID33802371
PMCPMC8001283

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.