Evidence map›Paper›PMID 33802356›Full record

ReviewMicromachines2021

Inertial Microfluidics Enabling Clinical Research.

Srivathsan Kalyan, Corinna Torabi, Harrison Khoo, Hyun Woo Sung, Sung-Eun Choi, Wenzhao Wang, Benjamin Treutler, Dohyun Kim, Soojung Claire Hur

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Deciphering viscoelastic cell manipulation in rectangular microchannels.Physics of fluids (Woodbury, N.Y. : 1994) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Srivathsan KalyanDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.ORCID 0000-0003-0669-0156
Corinna TorabiDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
Harrison KhooDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
Hyun Woo SungDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
Sung-Eun ChoiDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.ORCID 0000-0001-7534-7824
Wenzhao WangDepartment of Biomedical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
Benjamin TreutlerDepartment of Biomedical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
Dohyun KimDepartment of Mechanical Engineering, Myongji University, Yongin-si 17508, Korea.ORCID 0000-0003-1833-9259
Soojung Claire HurDepartment of Mechanical Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.ORCID 0000-0002-4725-5540

Funding

Development of a microfluidic primary cell editing platform (pCEP) for personal gene therapyR21CA229024 · NCI · JOHNS HOPKINS UNIVERSITY · PI HUR, SOOJUNG CLAIRE · 2020 to 2022
$551k
NCI NIH HHS R21 CA229024NIH HHS 1R21CA229024
6 · The paper itself

Abstract

Fast and accurate interrogation of complex samples containing diseased cells or pathogens is important to make informed decisions on clinical and public health issues. Inertial microfluidics has been increasingly employed for such investigations to isolate target bioparticles from liquid samples with size and/or deformability-based manipulation. This phenomenon is especially useful for the clinic, owing to its rapid, label-free nature of target enrichment that enables further downstream assays. Inertial microfluidics leverages the principle of inertial focusing, which relies on the balance of inertial and viscous forces on particles to align them into size-dependent laminar streamlines. Several distinct microfluidic channel geometries (e.g., straight, curved, spiral, contraction-expansion array) have been optimized to achieve inertial focusing for a variety of purposes, including particle purification and enrichment, solution exchange, and particle alignment for on-chip assays. In this review, we will discuss how inertial microfluidics technology has contributed to improving accuracy of various assays to provide clinically relevant information. This comprehensive review expands upon studies examining both endogenous and exogenous targets from real-world samples, highlights notable hybrid devices with dual functions, and comments on the evolving outlook of the field.

Indexed as

cell purificationclinical researchhigh throughputhybrid devicesinertial microfluidicssample processingtranslational research

Identifiers

PMID33802356
PMCPMC7999476

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.